Tag: Pharmacology
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Going With the Ion Flow
Northwestern Medicine scientists are diving deep into the structure and function of ion channels to inform new therapies.
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Mechanism Behind Insensitivity to Pain Discovered
A new study explains how mutations in a sodium channel can lead to a disorder causing insensitivity to pain.
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New Insights Into Sodium Channel Structure
Northwestern Medicine scientists have mapped the complete structure of a voltage-gated sodium channel, proteins in the membrane of cells that play an important role in many diseases.
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Using Stem Cells to Predict Toxicity of Chemotherapy Drugs
A Northwestern Medicine study has established a new safety index for a common group of chemotherapy drugs, by using a stem cell model to screen such therapies for cardiotoxicity.
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Understanding How Calcium Channels Open and Close
Northwestern Medicine scientists identified the process by which a calcium channel called the CRAC channel opens and closes, and how mutations in the channel structures that control its opening cause disease.
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Insights Into Enzyme Targets Could Lead to New Cancer Therapies
Northwestern Medicine scientists have identified the unique targets of two enzymes that activate ubiquitination, a key modification of proteins that controls a variety of cellular processes.
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Celebrating a Half-Century of Leadership in Bone Biology
Former and current colleagues, students and friends gathered to celebrated the career of Paula Stern, PhD, an authority on bone and mineral health research, and a respected leader and educator.
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New Insights Into Signaling Pathway Could Lead to Novel Therapies for Neurological Disorders
Northwestern Medicine scientists have demonstrated an alternate method of signaling used by proteins called group I metabotropic glutamate receptors, a finding that could be used to develop novel drug treatments for many neurological disorders.
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New Insights Into Mechanisms Behind Polycystic Kidney Disease
A new study shows potential mechanisms leading to the activation of a mutated gene in autosomal dominant polycystic kidney disease.
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Identifying Blood Cell Contribution to Inflammation After Seizures
Northwestern Medicine scientists co-authored a study that identified a blood cell not normally found in the healthy brain that can invade brain tissue after status epilepticus, a type of seizure, and contributes to inflammation.
