Improving Treatment for Triple-Negative Breast Cancer
A team led by Northwestern Medicine investigators has identified a novel molecular target that may improve the efficacy of current treatments for triple-negative breast cancer.
Browsing: "Pharmacology"
New Insights into Synaptic Plasticity
Calcium channels commonly found in immune cells are also present in the brain and regulate synaptic plasticity, according to a recently published study.
Novel “Gate Latch” Mechanism Essential for Activation of Immune System
Northwestern Medicine investigators have identified a novel “gate latch” mechanism within the Orai1 ion channel that is essential for proper activation of the immune system.
Uncovering the Impact of Protein Mutations in Parkinson’s
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.
Proteins on Neuron Surfaces Prove Pivotal for Communication
A cell-surface protein is essential for proper microcircuit function in the brain, according to a study published in Nature Communications.
Using Stem Cells for Drug Discovery
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
Rocklin Receives NIH New Innovator Award
Gabriel Rocklin, PhD, assistant professor of Pharmacology, has received the NIH Director’s New Innovator Award, an early-career grant supporting unconventional research projects in the biomedical, behavioral or social sciences.
Propelling Synthetic Biology into the Future
In the past decade, synthetic biology — the reengineering of organisms and their genetic information so they can produce a new substance or gain a new ability — has rapidly emerged to the forefront of modern-day science. Northwestern’s Center for Synthetic Biology has been leading the way.
Study Reveals Molecular Mechanisms Behind Genetic Kidney Disease
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
African Ancestry Affects Gene Expression
Levels of African ancestry in a person’s genome determines the level at which certain genes are expressed, findings that could offer insight into the different risk of diseases.