Category: Disease Discoveries
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Immunotherapy Strategy Shows Promise for Deadly Brain Cancer
A new immunotherapy strategy has shown promise in targeting one of the most aggressive and deadly forms of brain cancer, according to a new study published in Nature.
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Understudied Enzyme Helps Pathogen Prosper, Study Finds
A new study published in the Proceedings of the National Academy of Sciences has offered insight into how Staphylococcus aureus, a major human pathogen, fine-tunes its internal RNA degradation machinery to survive stress and potentially cause infection.
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Identifying Immune Pathways Driving Aggressive Brain Cancers
A new study has uncovered a key mechanism that helps one of the deadliest brain cancers evade the immune system, according to the study published in The Journal of Clinical Investigation.
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Intracellular Mechanisms Promote Tumor Survival During Hypoxia
Northwestern Medicine scientists have for the first time described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advances.
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Lymphatic Dysfunction Drives Heart Valve Disease
Dysfunction in the lymphatic system has been identified as a hidden driver of life‑threatening heart valve disease in patients with Marfan syndrome, according to a new Northwestern Medicine study published in The Journal of Clinical Investigation.
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Immune Cell Circuit Restores Barrier Function in IBD
Scientists have discovered a new communication circuit between immune cells in the intestines, a potential therapeutic target to improve inflammatory bowel disease outcomes, according to a recent study published in the Proceedings of the National Academy of Sciences.
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Expanding the Evidence for Behavioral Interventions in Gastroenterology
The Division of Gastroenterology and Hepatology at Feinberg has a distinct strength in understanding how behavior and lifestyle influence gastrointestinal (GI) health. The Division conducts research aimed at improving treatments for disorders of the digestive tract and related organs.
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Exploring Intracellular Communication to Understand Neurodegeneration
Investigators have uncovered a new communication pathway between mitochondria and RNA granules that may improve the understanding of how the toxic buildup of the TDP-43 protein leads to the development of certain neurodegenerative diseases, according to a recent study published in Nature Communications.
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Bacteria ‘Rewire’ Epithelial Cells and Drive Disease in the Gut
A bacterial pathogen that causes colitis and colorectal cancer creates a nutrient-rich niche and “rewires” epithelial cell signaling in the inflamed gut, which promotes bacterial colonization and disease, mechanisms that may be promising therapeutic targets, according to a recent study published in the journal Cell.
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Immune Biomarkers May Predict Response to Bladder Cancer Treatment
A Northwestern Medicine study has offered new clues as to why immunotherapy works well for some bladder cancer patients but fails for others, according to a study published in the Journal of Clinical Investigation.
