Category: Disease Discoveries
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Noncoding DNA Regions Drive Development of Neurodevelopmental Disorders
A new study from the laboratory of Gemma Carvill, PhD, has uncovered variants in noncoding regulatory regions of the genome that contribute to the development of neurodevelopmental disorders, findings that could help spearhead the development of more effective precision therapeutic strategies.
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Exploring Genetic Differences in Parkinson’s Disease by Ancestry
A landmark international study has found that the genetic drivers of Parkinson’s disease can vary dramatically between populations, underscoring the need to include people of various ancestries in genetic research and clinical trials.
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Parkinson’s Gene Linked to Early Dysfunction in Brain Cells
Northwestern Medicine scientists have uncovered how a major Parkinson’s disease gene disrupts the brain’s most vulnerable dopamine-producing neurons before detectable neuronal loss, according to findings published in Nature Communications.
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Study Identifies New Genetic Variants that Cause Rare Tumor Disorder
A recent Northwestern Medicine study offers new data showing previously unknown genetic variants that cause the development of tuberous sclerosis complex, a rare genetic disorder that causes benign tumors to develop in many parts of the body, according to findings published in Nature Communications.
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AI-Guided Study Uncovers Drug Targets for Psoriasis
A new study from Northwestern Medicine investigators, in collaboration with Biohub, a program of the Chan Zuckerberg Initiative, has identified potential drug targets for treating psoriasis, according to the study published in Nature Communications.
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‘Leaky’ Muscle Fibers Drive Immune Response in Muscular Dystrophy
A Northwestern Medicine study has uncovered how chronic defects in muscle membrane repair can fuel harmful inflammation, according to the study published in JCI Insight.
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Daylight Saving Time Impacts Risk of Retinal Vascular Disease
For the first time, Northwestern Medicine scientists have detailed how autumn and spring daylight saving time transitions impact a person’s risk of developing retinal vascular disease, according to a recent study published in Scientific Reports.
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Radiotherapy Reprograms Immune Response in Rare Skin Cancer
A new Northwestern Medicine study has discovered how radiotherapy alters the immune environment within cutaneous T-cell lymphoma tumors, revealing new molecular signatures associated with long-term treatment response and tumor recurrence.
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Intricate Molecular Mechanisms Help Bacteria Evade Immune Detection
Northwestern scientists have identified a novel mechanism utilized by the bacteria responsible for gonorrhea to evade immune detection and achieve widespread infection, according to a recent study published in the Proceedings of the National Academy of Sciences.
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Immunotherapy Strategy Shows Promise for Deadly Brain Cancer
A new immunotherapy strategy has shown promise in targeting one of the most aggressive and deadly forms of brain cancer, according to a new study published in Nature.
