Tag: Pharmacology
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Novel “Gate Latch” Mechanism Essential for Activation of Immune System
Northwestern Medicine investigators have identified a novel “gate latch” mechanism within the Orai1 ion channel that is essential for proper activation of the immune system.
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Uncovering the Impact of Protein Mutations in Parkinson’s
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.
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Proteins on Neuron Surfaces Prove Pivotal for Communication
A cell-surface protein is essential for proper microcircuit function in the brain, according to a study published in Nature Communications.
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Using Stem Cells for Drug Discovery
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
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Rocklin Receives NIH New Innovator Award
Gabriel Rocklin, PhD, assistant professor of Pharmacology, has received the NIH Director’s New Innovator Award, an early-career grant supporting unconventional research projects in the biomedical, behavioral or social sciences.
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Propelling Synthetic Biology into the Future
In the past decade, synthetic biology — the reengineering of organisms and their genetic information so they can produce a new substance or gain a new ability — has rapidly emerged to the forefront of modern-day science. Northwestern’s Center for Synthetic Biology has been leading the way.
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Study Reveals Molecular Mechanisms Behind Genetic Kidney Disease
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
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African Ancestry Affects Gene Expression
Levels of African ancestry in a person’s genome determines the level at which certain genes are expressed, findings that could offer insight into the different risk of diseases.
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Experimental Drug May Reduce Cancer Growth and Progression
Scientists co-led by Sui Huang, MD, PhD, found an experimental drug called metarrestin significantly reduced metastasis and cancer progression in mouse models.
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Expanding Genetic Screening Guidelines for Colon Cancer
A new study provided evidence that current guidelines for genetic screenings for colorectal cancer-associated genes are missing patients and should be expanded.
