Tag: Pharmacology
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Improving the Design of New Protein Structures
Northwestern Medicine investigators have developed a novel approach for designing and testing new protein folds, which could be used to develop new therapeutics.
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Newly Identified Protein Drives Breast Cancer Stemness and Metastasis
Using machine learning, Northwestern scientists have demonstrated that the protein membrane CD81 interacts with CD44 in promoting tumor cell cluster formation and lung metastasis of triple negative breast cancer.
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Targeting Ion Channels to Manage Osteoarthritis Pain
Therapeutically targeting ion channels in nociceptor neurons may be a promising strategy for managing osteoarthritis pain, according to a Northwestern Medicine study.
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‘Inside Out’ Signaling Promotes Tumor Growth
An immune system kinase promotes tumor inflammation and progression, according to a study published in Nature Communications.
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Anti-seizure Medication has a New Target
Designed to target AMPAR receptors in the brain, the medication — called perampanel — also modulates kainate receptors.
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Dual Function Found for mRNA Modifier
An enzymatic modifier of messenger RNA has different functions depending on its location, according to a recent study.
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Expanded Role for Calcium Channels in T-Cells
A subunit of voltage-gated calcium channels was found to have a functional role in T-cells, according to a study published in Nature Communications.
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Higher Doses of Anti-Seizure Medications May Be Needed in Pregnancy
Higher doses of anti-seizure medications may be necessary during pregnancy, according to a recent study.
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Potassium Channel Dysfunction in Genetic Epilepsy
Northwestern Medicine scientists discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy.
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Arrhythmia Genes More Common Than Previously Thought
Sequencing known cardiac arrythmia genes in more than 20,000 people without an indication for genetic testing identified pathogenic variants in nearly one percent of individuals.
