Category: Disease Discoveries
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New Signaling Pathway in Brain Tumors Identified
Northwestern Medicine scientists identified a previously unknown signaling pathway that enhances tumor growth in glioblastomas and head and neck cancers. The proteins in the pathway could be targeted in the treatment of human cancers.
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New Target for Huntington’s Disease Therapy
Northwestern Medicine scientists have proven an old therapeutic focus for Huntington’s disease wrong, and they propose a new one in its place.
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Proteins Involved in Blood and Bone Marrow Disease
Northwestern Medicine scientists have expanded the understanding of how myelodysplastic syndromes develop.
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Accelerating Diabetic Wound Healing
Depleting an enzyme called GM3 synthase with gene therapy may help diabetics heal wounds faster.
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Mighty Mitochondria Make Comeback as Sensitive Communicators
Navdeep Chandel, PhD, David W. Cugell Distinguished Professor in Medicine-Pulmonary and Cell and Molecular Biology, focuses on the role of metabolism and signaling in disease.
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Target Identified to Inhibit Prostate Cancer Cells
Prostate cancer cells producing too much PIM1 are particularly sensitive to the inhibition of a protein called polo-like kinase (PLK1).
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Air Pollution Shown to Increase Lung Inflammation and Blood Clots
Northwestern Medicine scientists demonstrate that exposure to air pollution causes a stress response characterized by elevation in the level of the stress hormone adrenaline.
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The Role of Signaling Pathways in Painful Diabetic Neuropathy
Daniela Menichella, MD, PhD, assistant professor in Neurology, studies the mechanism and role of the protein chemokine SDF-1 and its receptor CXCR4 in Painful Diabetic Neuropathy.
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Study Helps Explain Chronic Inflammation in Colon Cancer
Scientists from Northwestern Medicine and the University of Chicago identified elevated levels of a regulatory protein called beta-catenin in the T-cells of patients with colon cancer.
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Investigating Follicle Development
Robin Skory, an MD/PhD student, worked in the lab of Teresa Woodruff, PhD, to study follicle development and fertility preservation.
