Category: Disease Discoveries
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Novel Injectable Therapy Shows Promise in Treating Crohn’s Disease
A team of Northwestern investigators has demonstrated that injection of anti-inflammatory peptide amphiphiles into intestinal lesions can reduce inflammation in an animal model of Crohn’s disease.
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Leukemia Hijacks Nucleotide Metabolism
T-cell acute lymphoblastic leukemia hijacks a signaling pathway to produce nucleotides, a basic building block of life that fuels the growth and spread of the cancer, according to a recent study.
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Why Black Men’s Prostate Cancer May be More Responsive to Immunotherapy
A new Northwestern Medicine study has discovered why Black men die more often of prostate cancer yet also have greater survival benefits from immunotherapy treatments.
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Plotting the Neural Circuitry of Appetite Suppression
Northwestern Medicine scientists have uncovered a neural circuit that drives fear-induced suppression of feeding, according to a study published in Neuron.
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Cardio-Kidney Trials Present Obstacles
A new class of drugs shows benefit for both cardiovascular and kidney conditions, but scientists should be cautious in designing trials that include both cardiovascular and kidney outcomes in the same analysis, according to a Northwestern Medicine review article.
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Addressing Racial and Ethnic Disparities in COVID-19 Hospitalizations, Outcomes
Overall mortality for patients hospitalized for COVID-19 in the U.S. during the first half of 2020 was 18.4 percent, with more than half of all deaths occurring in Black and Hispanic patients, according to findings published in the journal Circulation.
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New Developments in Parkinson’s Pathology
The strength of neuron-to-neuron connections does not govern the spread of Parkinson’s disease in the brain, according to a recent study.
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Proxy Measures Fail to Assess Cardiovascular Care
Using proxy measures of preparedness for hypertension or diabetes care did not accurately assess the ability of low- and middle-income countries to treat patients, according to a study published in PLOS Medicine.
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Exploring the Relationship Between Inflammation and Heart Failure
The presence of inflammatory proteins was associated with comorbidity burden and deteriorating heart function in patients with heart failure with preserved ejection fraction, according to a Northwestern Medicine study.
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Cilia Defects Linked to Schizophrenia
Mutations in PCM1, a gene involved in the formation of cilia, were linked with schizophrenia in a variety of animal models and in human genome analysis, according to a recent study.
