Investigators led by Barbara Stranger, PhD, associate professor of Pharmacology, developed a guide outlining best practices for studying and testing sex-dependent genetic effects in complex traits and diseases, published in the journal Cell.
Northwestern Medicine investigators have identified new genetic variations effecting gene expression in the liver cells of patients of African descent, findings that provide insight into how drugs are metabolized differently in different populations.
Targeting calcium signaling in neurons may represent a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study.
Northwestern Medicine investigators have discovered that specific calcium channels help regulate sex differences in the functioning of immune cells for neuroinflammation and overall neuropathic pain.
A team of Northwestern investigators led by Peter Penzes, PhD, has developed a new therapy that could treat Phelan-McDermid syndrome, a subtype of autism spectrum disorder.
Northwestern Medicine investigators have developed a novel approach for designing and testing new protein folds, which could be used to develop new therapeutics.
Using machine learning, Northwestern scientists have demonstrated that the protein membrane CD81 interacts with CD44 in promoting tumor cell cluster formation and lung metastasis of triple negative breast cancer.
Therapeutically targeting ion channels in nociceptor neurons may be a promising strategy for managing osteoarthritis pain, according to a Northwestern Medicine study.
An immune system kinase promotes tumor inflammation and progression, according to a study published in Nature Communications.
Designed to target AMPAR receptors in the brain, the medication — called perampanel — also modulates kainate receptors.