Tag: Pharmacology
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New Genetic Variants Linked to Brain Malformation
More cases of children born with abnormal brain development may have genetic explanations than previously thought, according to a recent study published in JAMA Neurology.
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Pioneering New Methods to Understand Protein Folding
Northwestern Medicine scientists have developed a new technique for measuring protein folding stability on an unprecedented scale, according to a new study published in Nature.
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Study Identifies Novel Regulators of Hippocampal Overactivity
Reduced expression of specific calcium channels impaired electrical signaling between neurons and contributed to the onset of behaviors associated with neurodevelopmental disorders and seizure susceptibility in mouse models, according to a Northwestern Medicine study.
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New Therapeutic Target for Osteoarthritis Identified
Investigators have discovered that a subset of sensory neurons promote osteoarthritis-related joint pain and inflammation, suggesting a new therapeutic target for pain management, according to findings published in Nature Communications.
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Newly Discovered Mechanisms Increase Chemotherapy Resistance in Breast Cancer
Northwestern Medicine investigators have discovered novel features of circulating tumor stem cells that can promote chemotherapy evasion and metastasis in triple-negative breast cancer, according to a recent study.
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Improving the Study of Sex-Based Differences in Complex Traits and Disease
Investigators led by Barbara Stranger, PhD, associate professor of Pharmacology, developed a guide outlining best practices for studying and testing sex-dependent genetic effects in complex traits and diseases, published in the journal Cell.
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Genetic Variations Influence Drug Metabolism in Patients of African Descent
Northwestern Medicine investigators have identified new genetic variations effecting gene expression in the liver cells of patients of African descent, findings that provide insight into how drugs are metabolized differently in different populations.
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Potential Therapeutic Target for Schizophrenia Identified
Targeting calcium signaling in neurons may represent a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study.
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Calcium Channels Regulate Neuroinflammation and Neuropathic Pain
Northwestern Medicine investigators have discovered that specific calcium channels help regulate sex differences in the functioning of immune cells for neuroinflammation and overall neuropathic pain.
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Northwestern Investigators Develop New Therapy for Autism Subtype
A team of Northwestern investigators led by Peter Penzes, PhD, has developed a new therapy that could treat Phelan-McDermid syndrome, a subtype of autism spectrum disorder.
