Scientists discovered a previously unknown receptor site in a voltage-gated sodium channel, suggesting that a commonly-used cancer drug could be used to target this channel and relieve pain.
For the first time, Northwestern Medicine scientists have characterized how a genetic mutation associated with pediatric epilepsy affects neuron activity.
A team led by Northwestern Medicine investigators has identified a novel molecular target that may improve the efficacy of current treatments for triple-negative breast cancer.
Calcium channels commonly found in immune cells are also present in the brain and regulate synaptic plasticity, according to a recently published study.
Northwestern Medicine investigators have identified a novel “gate latch” mechanism within the Orai1 ion channel that is essential for proper activation of the immune system.
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.
A cell-surface protein is essential for proper microcircuit function in the brain, according to a study published in Nature Communications.
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
Gabriel Rocklin, PhD, assistant professor of Pharmacology, has received the NIH Director’s New Innovator Award, an early-career grant supporting unconventional research projects in the biomedical, behavioral or social sciences.
In the past decade, synthetic biology — the reengineering of organisms and their genetic information so they can produce a new substance or gain a new ability — has rapidly emerged to the forefront of modern-day science. Northwestern’s Center for Synthetic Biology has been leading the way.