Tag: Biochemistry and Molecular Genetics
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Identifying Mechanisms of Methylation in Stem Cells
Northwestern Medicine scientists identified critical regulatory processes that govern differentiation in embryonic stem cells.
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Transcription Factors Cooperate to Promote Cancer Growth
A well-established cancer cell transcription factor and its newly identified co-factor work together to drive cancer cell proliferation, according to a Northwestern Medicine study published in Science Advances.
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Glucocorticoids Enhance Muscles Through Sex-Specific Pathways
Glucocorticoid steroids improved muscle performance through distinct, sex-specific mechanisms, according to a Northwestern Medicine study.
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Investigators Identify New Connections Between Circadian Rhythm and Muscle Repair
Northwestern Medicine investigators have discovered a novel mechanism that connects circadian rhythm-controlled cellular metabolism and regeneration with muscle repair after injury.
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Genetic Variant of High-risk Childhood Leukemia Revealed
A genetic mutation changing just one base pair of nucleotides greatly increases risk of a lethal subtype of childhood acute lymphoblastic leukemia, according to a recent study.
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Protein ‘Chaperone’ Plays Dual Role in DNA Replication
The protein UBR7 acts as a histone chaperone and regulates nucleotide metabolism, making UBR7 among the first proteins known to affect both processes.
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Histone Protein Influences Both Neurological Disorder and Cancer
Mutations in a histone regulator protein are connected to both a rare neurodevelopmental disorder and to some cancers, according to a recent study.
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Study Shows Epigenetic Modification is Central for Tumor Metastasis
Fatty acid uptake produces an epigenetic modification that is required for cancer metastasis, according to a study published in Nature.
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Transcription Elongation Checkpoint Discovered
Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template.
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New Method to Untangle 3D Cancer Genome
Northwestern Medicine scientists have described a method of reconstructing the three-dimensional structure of chromosomes in cancer cells and matching those chromosomes with counterpart oncogenes.
