New Method to Untangle 3D Cancer Genome
Northwestern Medicine scientists have described a method of reconstructing the three-dimensional structure of chromosomes in cancer cells and matching those chromosomes with counterpart oncogenes.
Browsing: "Biochemistry-and-molecular-genetics"
Prindle Honored with Army Research Office Early Career Award
Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, has been honored with the Early Career Award for Scientists and Engineers from the U.S. Army Research Office.
3D Genome Structure Influences Cancer
For the first time, scientists have examined how the three-dimensional structure of chromatin can play a part in the development of bladder cancer and pediatric brain tumors, according to a pair of Northwestern Medicine studies.
Identifying New Targeted Therapy Approaches for Leukemia
Using small molecular inhibitors to block the BAP1 complex may be a promising targeted therapy approach for leukemia, according to a Northwestern Medicine study published in Nature Cancer.
New Method to Analyze Nucleosomes
Northwestern Medicine scientists have developed Nuc-MS, a new method to capture the protein composition of whole nucleosomes without losing information.
Understanding Epigenetic Regulators in Neurodevelopmental Diseases and Cancer
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
Inhibiting SAM Biosynthesis to Slow Tumor Growth
Inhibiting production of a key material produced by the mTOR pathway could slow tumor growth, according to a recent Northwestern Medicine study.
Next-Gen Sequencing
Northwestern’s investment in next-generation sequencing is leading to unprecedented avenues of discovery.
Leukemia Hijacks Nucleotide Metabolism
T-cell acute lymphoblastic leukemia hijacks a signaling pathway to produce nucleotides, a basic building block of life that fuels the growth and spread of the cancer, according to a recent study.
Uncovering How Protein Complexes Impact Gene Expression
Northwestern Medicine scientists have detailed the diverse function of CDK9-containing complexes and their impact on gene expression in a recent study published in the journal Genes and Development.