New Drug Target for Treatment-Resistant Prostate Cancer
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
Browsing: "Biochemistry-and-molecular-genetics"
Understanding Mitochondrial Dysfunction’s Impact on Neurological Diseases
A recent Northwestern Medicine study may improve the understanding of mitochondrial dysfunction and its impact on the development of neurological diseases.
New Machine-learning Method to Identify Chromatin Loops
A machine-learning program called Peakachu can reveal previously unknown chromatin loops, according to a Northwestern Medicine study published in Nature Communications.
Mitochondrial Metabolism Shows Promise as Target for Cancer Therapy
Northwestern Medicine investigators have discovered that the growth of cancerous tumors requires the activation of a specific biochemical process within the mitochondria of tumor cells, showing potential as a new target for cancer therapy.
Propelling Synthetic Biology into the Future
In the past decade, synthetic biology — the reengineering of organisms and their genetic information so they can produce a new substance or gain a new ability — has rapidly emerged to the forefront of modern-day science. Northwestern’s Center for Synthetic Biology has been leading the way.
Gift Names Epigenetics Institute at Feinberg
A new $15 million gift from University trustees and supporters Louis A. Simpson and Kimberly K. Querrey will establish the Simpson Querrey Institute for Epigenetics at Northwestern University Feinberg School of Medicine, boosting the school’s current efforts to study the effects of environment on the regulation of gene expression.
Rewriting the Role of a Transcription Factor
A DNA transcription mechanism does not work as previously thought, according to a new Northwestern Medicine study.
Chromatin Organizes Itself Into 3D ‘Forests’ in Single Cells
Using mathematical modeling and optical imaging they developed themselves, a Northwestern University research team has discovered how chromatin folds at the single-cell level.
Disorderly DNA Helps Cancer Cells Evade Treatment
A new Northwestern University study has discovered that the packing of the three-dimensional genome structure, called chromatin, controls how cells respond to stress.
New Link Between Mitochondria and Neurodegeneration
A study published in the Journal of Cell Biology showed that mitochondrial stress in neurons can cause an enzyme imbalance that contributes to neuronal dysfunction and death.