Tag: Biochemistry and Molecular Genetics
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‘Leaky’ Muscle Fibers Drive Immune Response in Muscular Dystrophy
A Northwestern Medicine study has uncovered how chronic defects in muscle membrane repair can fuel harmful inflammation, according to the study published in JCI Insight.
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Examining the Impact of Aging on Critical Cellular Processes
A new Northwestern Medicine study published in the Proceedings of the National Academy of Sciences has explored the impacts of aging on essential cellular processes, findings that could shape the development of future anti-aging therapeutic strategies.
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Intracellular Mechanisms Promote Tumor Survival During Hypoxia
Northwestern Medicine scientists have for the first time described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advances.
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Blood Test May Predict Immunotherapy Response in Head and Neck Cancer
A new Northwestern Medicine study suggests that a simple blood test could help identify which patients with head and neck cancer are most likely to benefit from immunotherapy, according to a study published in the Journal of Clinical Investigation.
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Novel Synthetic Biomolecule Degrades Disease-Related Proteins
Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can target and degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study.
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‘Toxic’ Molecule Plays Vital Role in Gene Regulation and Development
A molecule once thought to be a harmful metabolic byproduct may play a crucial role in early development and gene regulation, according to a new study published in Nature that challenges decades of biochemical assumptions.
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Metformin Slows Mitochondrial Energy Production, Promotes Glycemic Control
A new Northwestern Medicine study has found that metformin, a commonly prescribed diabetes drug, focuses primarily on the gut, acting to prevent glucose levels rising in the blood by driving glucose utilization inside cells lining the intestine.
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Visionary Biochemist Delivers 2026 Kimberly Prize Lecture
Svetlana Mojsov, PhD, delivered the 2026 Kimberly Prize Lecture on April 20, drawing on decades of groundbreaking research that helped transform the treatment of diabetes and obesity.
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New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies
Northwestern Medicine scientists have discovered new mechanisms underlying transcriptional initiation and elongation control that support proper gene expression, which may inform targeted therapeutic approaches for many diseases, according to a recent study published in Molecular Cell.
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Understanding the Link Between Nucleotide Metabolism and Chromatin Assembly
A Northwestern Medicine study has revealed a connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, according to findings published in Molecular Cell.
