Protein ‘Chaperone’ Plays Dual Role in DNA Replication
The protein UBR7 acts as a histone chaperone and regulates nucleotide metabolism, making UBR7 among the first proteins known to affect both processes.
Browsing: "Biochemistry-and-molecular-genetics"
Histone Protein Influences Both Neurological Disorder and Cancer
Mutations in a histone regulator protein are connected to both a rare neurodevelopmental disorder and to some cancers, according to a recent study.
Study Shows Epigenetic Modification is Central for Tumor Metastasis
Fatty acid uptake produces an epigenetic modification that is required for cancer metastasis, according to a study published in Nature.
Transcription Elongation Checkpoint Discovered
Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template.
New Method to Untangle 3D Cancer Genome
Northwestern Medicine scientists have described a method of reconstructing the three-dimensional structure of chromosomes in cancer cells and matching those chromosomes with counterpart oncogenes.
Prindle Honored with Army Research Office Early Career Award
Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, has been honored with the Early Career Award for Scientists and Engineers from the U.S. Army Research Office.
3D Genome Structure Influences Cancer
For the first time, scientists have examined how the three-dimensional structure of chromatin can play a part in the development of bladder cancer and pediatric brain tumors, according to a pair of Northwestern Medicine studies.
Identifying New Targeted Therapy Approaches for Leukemia
Using small molecular inhibitors to block the BAP1 complex may be a promising targeted therapy approach for leukemia, according to a Northwestern Medicine study published in Nature Cancer.
New Method to Analyze Nucleosomes
Northwestern Medicine scientists have developed Nuc-MS, a new method to capture the protein composition of whole nucleosomes without losing information.
Understanding Epigenetic Regulators in Neurodevelopmental Diseases and Cancer
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.