Streamlining Chemical-Genetic Screening
Northwestern Medicine scientists have developed a new high-throughput sequencing tool to test how drugs interact with genetically modified cells.
Browsing: "Biochemistry-and-molecular-genetics"
Discovering New Mechanisms in Epigenetics
A series of recent discoveries by Northwestern Medicine scientists point to a more nuanced understanding of how epigenetic regulators function.
Mitochondria-Targeted Antioxidants Inhibit Tumor Growth
Northwestern Medicine investigators have discovered that inserting dietary antioxidants into the mitochondria of cancer cells may inhibit overall tumor growth.
Scientists Unravel Zebrafish Epigenome
A new Northwestern Medicine study has identified tissue-specific epigenetic regulators in zebrafish, filling in a longtime gap in the understanding of the organism’s genome.
Unusual Epigenetic Regulator Could Impact Cancer
A newly discovered function of an epigenetic regulator could be a key to new cancer treatments, according to a new study published in Genes and Development.
New Details on T-Cell Methylation
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
New Drug Target for Treatment-Resistant Prostate Cancer
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
Understanding Mitochondrial Dysfunction’s Impact on Neurological Diseases
A recent Northwestern Medicine study may improve the understanding of mitochondrial dysfunction and its impact on the development of neurological diseases.
New Machine-learning Method to Identify Chromatin Loops
A machine-learning program called Peakachu can reveal previously unknown chromatin loops, according to a Northwestern Medicine study published in Nature Communications.
Mitochondrial Metabolism Shows Promise as Target for Cancer Therapy
Northwestern Medicine investigators have discovered that the growth of cancerous tumors requires the activation of a specific biochemical process within the mitochondria of tumor cells, showing potential as a new target for cancer therapy.