The protein UBR7 acts as a histone chaperone and regulates nucleotide metabolism, making UBR7 among the first proteins known to affect both processes.
Mutations in a histone regulator protein are connected to both a rare neurodevelopmental disorder and to some cancers, according to a recent study.
Fatty acid uptake produces an epigenetic modification that is required for cancer metastasis, according to a study published in Nature.
Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template.
Northwestern Medicine scientists have described a method of reconstructing the three-dimensional structure of chromosomes in cancer cells and matching those chromosomes with counterpart oncogenes.
Arthur Prindle, PhD, assistant professor of Biochemistry and Molecular Genetics, has been honored with the Early Career Award for Scientists and Engineers from the U.S. Army Research Office.
For the first time, scientists have examined how the three-dimensional structure of chromatin can play a part in the development of bladder cancer and pediatric brain tumors, according to a pair of Northwestern Medicine studies.
Using small molecular inhibitors to block the BAP1 complex may be a promising targeted therapy approach for leukemia, according to a Northwestern Medicine study published in Nature Cancer.
Northwestern Medicine scientists have developed Nuc-MS, a new method to capture the protein composition of whole nucleosomes without losing information.
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.