Category: Disease Discoveries
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How Cells Defend Against Influenza A Virus
Human cells use a protein named TBC1D5 to “trap and kill” influenza A viruses inside host cells, but the virus encodes its own protein to disable this defense.
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Of Balding Mice and Men and Women
A newly discovered cause of balding in aging male mice could reveal a cause of hair loss in men and women as well, reports a study from Northwestern Medicine scientists.
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Anti-Cancer Inhibitor Could Have Dual Effect
TG2, an enzyme known to help cancers spread more quickly, also plays a role in regulating T-cells — opening the door to dual inhibition, according to a recent Northwestern Medicine study.
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Study Identifies Expanded Role for Metabolic Enzyme in Kidney Cancer
The underexpression of a specific metabolic enzyme is a common and adverse epigenetic modulating feature in clear cell renal cell carcinoma, which accounts for 80 percent of all kidney cancers, according to a recent study.
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Lewy Body Dementia Exacerbated by Immune Response
T-cells respond to buildup of alpha-synuclein with a harmful auto-immune response, according to a Northwestern Medicine study published in Science.
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Machine-learning Model Can Detect Rare Cardiomyopathy
A machine learning model can identify patients at risk of a rare cardiomyopathy, according to a recent study.
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Northwestern Scientists Explore Impacts of Genomic Variation in Disease in NIH Project
Northwestern is part of the Impact of Genomic Variation on Function (IGVF) Consortium, a $185 million National Institutes of Health (NIH) project that will explore the millions of genetic variants that cause disease around the world.
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Skin Cancer Harbors Targetable Mutation
An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in the JAK-STAT pathway, according to a recent Northwestern Medicine study.
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Translational Science: Glioblastoma
Northwestern’s Brain Tumor SPORE — part of the Lurie Cancer Center — is now three years old, and the bench to bedside process is producing results.
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Improving Immune Response Against Viral Infections and Disease
Blocking an inhibitory pathway within a subset of specialized T-cells may improve overall immune response against virally driven cancers, according to findings published in Nature.
