Tag: Pharmacology
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Developing Deep Learning Models to Understand the Human Genome
Northwestern Medicine scientists have developed a deep learning algorithm accelerating research around diseases and disorders that occur when the process of DNA transcription goes awry.
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Novel Approaches for Correcting Gene Expression Insufficiency
A new molecular technology capable of binding to mRNA and regulating gene expression may offer a new avenue for treating diseases caused by insufficient protein levels, according to a study published in Nature Communications.
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Investigating the Role of DNA Damage in Cardiac Hypertrophy
A novel cellular pathway regulates DNA damage and structural changes in cardiomyocytes which contributes to the development of cardiac hypertrophy according to a Northwestern Medicine study published in Circulation.
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Investigating the Link Between Iron Deficiency and Regulation of Cell Growth
Northwestern Medicine investigators have uncovered new mechanisms by which iron deficiency inhibits cell growth and proliferation in eukaryotic cells, findings that could improve the understanding of cancer growth and the development of targeted cancer therapies.
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Ion Channel Linked to Brain Inflammation Identified
Northwestern Medicine investigators have identified how a calcium channel in the nervous system contributes to brain inflammation, according to a study published in Nature Communications.
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Study Discovers Novel Therapeutic Target for Acute Respiratory Distress Syndrome
A new Northwestern Medicine study has discovered a novel therapeutic target and therapeutic agents for older patients with acute respiratory distress syndrome, according to recent findings published in Science Translational Medicine.
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New Genetic Variants Linked to Brain Malformation
More cases of children born with abnormal brain development may have genetic explanations than previously thought, according to a recent study published in JAMA Neurology.
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Pioneering New Methods to Understand Protein Folding
Northwestern Medicine scientists have developed a new technique for measuring protein folding stability on an unprecedented scale, according to a new study published in Nature.
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Study Identifies Novel Regulators of Hippocampal Overactivity
Reduced expression of specific calcium channels impaired electrical signaling between neurons and contributed to the onset of behaviors associated with neurodevelopmental disorders and seizure susceptibility in mouse models, according to a Northwestern Medicine study.
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New Therapeutic Target for Osteoarthritis Identified
Investigators have discovered that a subset of sensory neurons promote osteoarthritis-related joint pain and inflammation, suggesting a new therapeutic target for pain management, according to findings published in Nature Communications.
