Tag: Pharmacology
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Noncoding DNA Regions Drive Development of Neurodevelopmental Disorders
A new study from the laboratory of Gemma Carvill, PhD, has uncovered variants in noncoding regulatory regions of the genome that contribute to the development of neurodevelopmental disorders, findings that could help spearhead the development of more effective precision therapeutic strategies.
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Parkinson’s Gene Linked to Early Dysfunction in Brain Cells
Northwestern Medicine scientists have uncovered how a major Parkinson’s disease gene disrupts the brain’s most vulnerable dopamine-producing neurons before detectable neuronal loss, according to findings published in Nature Communications.
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Physiological Factors Reshape How Drugs and Proteins Interact
A new Northwestern Medicine study has demonstrated that proteins studied in simplified laboratory conditions don’t behave the same way in the human body, according to the study published in Nature Structural and Molecular Biology.
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New Experimental Method Reveals Protein Energy Landscapes on Larger Scale
Northwestern Medicine scientists have developed a new experimental method to analyze conformational fluctuations in protein domains on a uniquely large scale, which may improve data-driven modeling, biology and protein engineering, as detailed in a recent study published in Nature.
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Skin-Resident Immune Cells Drive Neuropathic Pain in Diabetes
In experimental models of diabetes, Northwestern Medicine scientists have discovered that a specialized group of skin-resident immune cells drive neuropathic pain through sex-dependent signaling pathways, according to a recent study published in The Journal of Clinical Investigation.
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Epilepsy Gene Implicated in Severe Migraine Disorder
Northwestern Medicine scientists have identified mutations in a gene coding for key ion channels in the brain as a new cause of a debilitating form of migraine, according to a study published in Brain.
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Overlooked Cells Linked to Poor Outcomes in Breast Cancer
A little-studied group of cancer cells circulating in the bloodstream may play a bigger role in breast cancer progression than previously thought, according to new research published in Science Translational Medicine that sheds light on how the disease spreads and why some patients fare worse than others.
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Advancing Epilepsy Research Through Genetic Insights
Epilepsy is one of the most common neurological disorders affecting nearly one percent of people worldwide. The Department of Pharmacology at Feinberg is leading research to understand the genetic causes of childhood-onset epilepsy, and to investigate what is happening perinatally to brain development in these cases.
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Calcium Signaling Channels Regulate Neuroinflammation and Motivation
Northwestern Medicine scientists have discovered how calcium signaling channels in the brain’s immune cells regulate neuroinflammation and promote the development of behaviors associated with affective mood disorders, according to a recent study published in Science Signaling.
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Trashing Cancer’s ‘Undruggable’ Proteins
Northwestern scientists have developed polymers capable of grabbing proteins and directing them to the cell’s waste-disposal machinery, potentially triggering cancer cell death.
