Tag: Pharmacology
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Investigating How Tumor-Immune Cell Clusters Drive Cancer Spread
In a pair of studies, investigators from the lab of Huiping Liu, MD, PhD, have uncovered how specific cellular interactions in the bloodstream may be fueling the spread of breast cancer.
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Successful Gene Editing Demonstrated for a Rare Neurodevelopmental Disorder
Scientists have implemented a novel gene-editing approach that may be an effective treatment for alternating hemiplegia of childhood (AHC), a rare neurodevelopmental disorder in children, according to a recent study published in Cell.
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Novel Molecular Mechanisms Inform Targeted Therapies for Chronic Kidney Disease
A recent Northwestern Medicine study has identified novel molecular mechanisms by which genetic mutations in the PKD2 gene cause the most common type of polycystic kidney disease, according to findings published in Proceedings of the National Academy of Sciences.
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Identifying New Therapeutic Strategies for Psychiatric Disorders
A new Northwestern Medicine study has identified the molecular mechanisms that cause a commonly prescribed antipsychotic drug to produce harmful side effects similar to Parkinson’s disease symptoms, according to findings published in Molecular Psychiatry.
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Novel Approach Improves Protein Characterization in Human Tissue
Scientists have developed a novel, robust proteomics technique that can more accurately identify and spatially characterize thousands of proteins in single cells within human tissue samples, as detailed in a recent study published in Nature Communications.
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Potential Therapeutic Targets for Genetic Heart Disorder Discovered
Investigators from Northwestern University Feinberg School of Medicine and Vanderbilt University School of Medicine have discovered new molecular mechanisms behind a genetic heart disorder that can increase the risk of sudden death in children and young adults, according to a recent study published in PNAS.
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Uncovering New Therapeutic Targets for Pediatric Epilepsy
Investigators in the laboratory of Gemma Carvill, PhD, have discovered novel molecular underpinnings of Dravet syndrome, a rare genetic form of epilepsy in children, that may serve as promising therapeutic targets, according to a recent study.
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Unravelling the Mysteries of Calcium Channel Regulation
Scientists have uncovered new insights into the molecular players behind calcium channel regulation, a biological process that coordinates a wide array of physiological responses, according to a study published in the Proceedings of the National Academy of Sciences.
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New Huntington’s Treatment Prevents Protein Aggregation in Mice
In research published in Science Advances, scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington’s disease, an incurable, debilitating illness that causes nerve cells to break down in the brain.
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Little-Studied RNA Might be Key to Regulating Genetic Disorders Like Epilepsy, Autism
Scientists have discovered an RNA that controls how much or how little protein is produced by a gene, with implications for neurodevelopmental disorders like epilepsy and autism.
