Tag: Genetics
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New Mechanism for Oncogenic Gene Splicing
Northwestern Medicine scientists have discovered an alternate mechanism for aberrant gene splicing that contributes to T-cell lymphoblastic leukemia, according to a recent study.
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Study Reveals Molecular Mechanisms Behind Genetic Kidney Disease
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
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Cancer Cells Hijack Nucleotide Metabolism to Boost Cell Proliferation
Mutations in the genes RAS and RAF allow cancer cells to create their own nucleotides, fueling cancer growth, according to a recent study published in Molecular Cell.
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Compound Influences Age-Related Decline in Circadian Rhythms
Supplementing lab animal diets with a chemical precursor of the molecule NAD+ countered certain age-related declines in circadian rhythm function, according to a recent study.
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Origin of Cancer Cells Influences Skin Cancer Prognosis
A new Northwestern Medicine study found important differences in rare skin lymphomas stemming from their specific cell of origin and clinical presentations, according to findings published in Nature Communications.
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New Function for Transcriptional Regulator Discovered
A new Northwestern Medicine study discovered a new and unexpected function for the transcriptional regulator MLL2/COMPASS.
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First Trial Shows Benefit for Genomically Targeted Prostate Cancer Treatment
For the first time, advanced prostate cancer has been treated based on the genomic makeup of the cancer, delaying disease progression for patients with a treatment-resistant form of prostate cancer.
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Genetic ‘Neighborhoods’ Fuel Leukemia
A new study has found that genetic alterations in a rare form of leukemia physically change the architecture of DNA, fueling the replication and spread of cancer cells.
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New Insights in Liver Zonation
A new Northwestern Medicine study has shed light on the complex phenomenon of liver zonation, showing that a protein known as Wnt is required for correct placement of tight junction and cell adhesion proteins within the liver.
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Using Genomics to Understand the Severity of Bacterial Infections
Northwestern Medicine investigators have uncovered a novel pathogenic mechanism used by the bacterium Pseudomonas aeruginosa to promote more severe infections.
