Genome Editing Made Possible on Cells Lining Blood Vessel Walls
The laboratory of YouYang Zhao, PhD, developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to vascular endothelial cells.
Browsing: "Genetics"
Secondary Structures in DNA are Associated With Cancer
A new Northwestern Medicine study reports that DNA manifested as knot-like folds and third rungs between DNA’s two strands may drive cancer development and an important regulatory enzyme could be associated with the formation of these unusual structures.
Protein ‘Chaperone’ Plays Dual Role in DNA Replication
The protein UBR7 acts as a histone chaperone and regulates nucleotide metabolism, making UBR7 among the first proteins known to affect both processes.
New Autism Biomarker Discovered in Cerebrospinal Fluid
Northwestern Medicine scientists have discovered a biomarker for one type of autism within cerebrospinal fluid, according to a recent study.
Histone Protein Influences Both Neurological Disorder and Cancer
Mutations in a histone regulator protein are connected to both a rare neurodevelopmental disorder and to some cancers, according to a recent study.
Uncovering the Degenerative Basis of Parkinson’s Disease
Northwestern investigators have discovered the molecular signature of a subset of dopaminergic neurons that increases their vulnerability to degeneration.
Fatty Acid Length Predicts Parkinson’s Disease Risk
Long chains of fatty acids in the lysosome are associated with a degenerative form of Gaucher disease, an inherited condition related to Parkinson’s disease.
Combination Therapy Reduces Toxic Aggregates in Parkinson’s Disease
A combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson’s disease-afflicted neurons, according to a recent study.
Study Shows Epigenetic Modification is Central for Tumor Metastasis
Fatty acid uptake produces an epigenetic modification that is required for cancer metastasis, according to a study published in Nature.
New Insights into the Mechanism of ALS
The damaging effects of toxic proteins created in one inherited form of amyotrophic lateral sclerosis (ALS) are mediated by an enzyme called SPOP.