Critical Function of Cilia Protein Discovered
A protein gives motile cilia part of their structure, according to a recent Northwestern Medicine study.
Browsing: "Genetics"
Chimeric Toxin Slows Cancer Growth
A novel compound using diphtheria toxin to attack a signaling pathway implicated in as many as 50 percent of cancers slowed tumor growth, according to a recent study.
New Role for RNA Splicing in Insulin Regulation
The gene transcription machinery that controls circadian rhythms also regulates insulin release in the pancreas, according to a Northwestern Medicine study.
New Genetic Regulators Could Improve Cancer Immunotherapy
A genetic screen has revealed previously unknown regulators of Foxp3, a transcription factor that, when deactivated, may improve patient response to aggressive cancers.
New Insights into Left Ventricular Cardiomyopathy
Genetic mutations in desmoplakin cause left ventricular cardiomyopathy, rather than right ventricular cardiomyopathy as previously believed, according to a recent study.
Novel Method Maps Virus-Host Protein Interactions
A novel method to map protein-protein interactions between viruses and their hosts more precisely than current methodologies may help improve the design of antiviral drugs and therapeutic strategies.
New Mechanism for Oncogenic Gene Splicing
Northwestern Medicine scientists have discovered an alternate mechanism for aberrant gene splicing that contributes to T-cell lymphoblastic leukemia, according to a recent study.
Study Reveals Molecular Mechanisms Behind Genetic Kidney Disease
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
Cancer Cells Hijack Nucleotide Metabolism to Boost Cell Proliferation
Mutations in the genes RAS and RAF allow cancer cells to create their own nucleotides, fueling cancer growth, according to a recent study published in Molecular Cell.
Compound Influences Age-Related Decline in Circadian Rhythms
Supplementing lab animal diets with a chemical precursor of the molecule NAD+ countered certain age-related declines in circadian rhythm function, according to a recent study.