A new Northwestern Medicine study, published in Genes and Development, has identified two DNA elements crucial to the activation of a set of genes that drive the early development of embryos.
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In research published in Nature Medicine, Northwestern Medicine scientists have found a molecule that stops the growth of an aggressive pediatric brain tumor for which there is no current treatment.
A paper published in Molecular Cell provides new insight into a protein complex called COMPASS and its function during histone methylation, a key modification that regulates gene expression.
Northwestern Medicine scientists have identified a molecular therapy to prevent the growth of a rare pediatric leukemia.
When it comes to gene regulation, there are more similarities between fruit flies and humans than previously thought, according to new Northwestern Medicine research.
Northwestern Medicine scientists explore research that has shown how the balanced activities of two protein families regulate gene expression during embryonic development and how mutations that tip this balance lead to cancer.
Navdeep Chandel, PhD, David W. Cugell Professor of Medicine, has received the National Cancer Institute’s Outstanding Investigator Award to explore how mitochondrial metabolism plays a role in cancer.
A transcription factor protein may play an important role regulating genomic imprinting, a phenomenon where one of the two gene copies inherited from parents is silenced.
Marcus Peter, PhD, professor of Medicine in the Division of Hematology/Oncology, and Ali Shilatifard, PhD, chair of Biochemistry and Molecular Genetics, and Maciej Lesniak, MD, chair of Neurological Surgery, have each been awarded seven-year, $6.4 million grants from the National Cancer Institute.
Northwestern Medicine scientists have identified the molecular machinery that releases paused gene expression, a finding that helps explain how important developmental genes jumpstart simultaneously.