Search results for: “shilatifard+published”
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Examining the Impact of Aging on Critical Cellular Processes
A new Northwestern Medicine study published in the Proceedings of the National Academy of Sciences has explored the impacts of aging on essential cellular processes, findings that could shape the development of future anti-aging therapeutic strategies.
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Intracellular Mechanisms Promote Tumor Survival During Hypoxia
Northwestern Medicine scientists have for the first time described the underlying mechanisms that regulate how cells rapidly change gene expression in response to hypoxia, a key feature of many treatment-resistant tumors, according to a recent study published in Science Advances.
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‘Toxic’ Molecule Plays Vital Role in Gene Regulation and Development
A molecule once thought to be a harmful metabolic byproduct may play a crucial role in early development and gene regulation, according to a new study published in Nature that challenges decades of biochemical assumptions.
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New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies
Northwestern Medicine scientists have discovered new mechanisms underlying transcriptional initiation and elongation control that support proper gene expression, which may inform targeted therapeutic approaches for many diseases, according to a recent study published in Molecular Cell.
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Exploring the Connection Between Gene Expression and Aging
Northwestern Medicine scientists have discovered how molecular “traffic controllers” in cells influence aging and cellular senescence — a state where cells stop dividing but remain metabolically active.
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Diabetes Drug May Protect Against Kidney Inflammation
A new study has shed light on how a class of diabetes drugs may protect the kidneys — not just by lowering blood sugar, but by triggering a molecular shift that dampens inflammation, according to the study published in The Journal of Clinical Investigation.
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Protein Implicated as Driver of Lung Cancer
Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression when it is mis-expressed in lung cancer, according to a study published in Science Advances.
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Novel Mechanism Eliminates ‘Bad’ Enzyme During Gene Expression
Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates ‘bad’ transcriptional elongation enzymes during gene expression, findings that may inform the understanding of adrenal diseases, according to a recent study published in Science Advances.
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Novel Technique May Accelerate Study of Gene Regulation
Investigators from the laboratory of Ali Shilatifard, PhD, have developed a novel technique to precisely and efficiently study gene regulation, which may accelerate the development of new therapeutic strategies, according to a recent study published in Molecular Cell.
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Understanding Cellular Transcription Responses to Oxygen Deprivation
A multiprotein complex is essential for regulating cellular transcription response to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.
