Category: Disease Discoveries
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Lysosome Dysfunction Linked to Infant Failure to Thrive
Neonatal intestinal disorders that prevent infants from getting the nutrients they need may be caused by defects in the lysosomal system, according to a new Northwestern Medicine study.
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Investigating Mechanisms of Fibrogenesis in Fetal Liver Disease
Peter Whitington, MD, professor in Pediatrics-Gastroenterology, Hepatology and Nutrition, found signaling pathways and tubule cell formation that drive fibrosis in gestational alloimmune liver disease.
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Mucus Proteins May Control Asthma
Sugars on a specific mucus protein can induce the death of a white blood cell called an eosinophil, which causes asthma, according to a new Northwestern Medicine study.
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A New Target for Improving Movement Symptoms of Parkinson’s Disease
Excessive brain plasticity in the subthalamic nucleus may be pivotal to abnormal brain activity and impaired movement in Parkinson’s disease, according to a new Northwestern Medicine study.
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Transcription Factor Regulates Repair Pathways in the Lung
In a new study, scientists found that the transcription factor EHF regulates pathways in respiratory epithelial cells that are important for repair of damaged cells and in maintaining the lung surface’s barrier function.
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Mechanisms of Rare Disorder May Shed Light on Parkinson’s Disease
A Northwestern Medicine study shows that lysosome dysfunction caused by a genetic mutation in patients with a rare Parkinson’s-like disorder leads to neurodegeneration, a finding that may link to common forms of the disease.
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Studying the Structural Causes and Consequences of Whiplash
Northwestern Medicine scientists have received a $1.6 million grant from the National Institutes of Health (NIH) to investigate the biological reasons that a quarter of all people with whiplash injury from motor vehicle collisions fail to fully recover in the long-term.
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Exploring How Arsenic Combats Leukemia
A Northwestern Medicine study unearthed the mechanisms behind arsenic’s anti-cancer effects to show how the chemical compound could combat multiple types of leukemia.
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Uncovering the Mechanisms Behind Recovery from Childhood Egg Allergies
Northwestern Medicine scientists uncovered that allergic children who develop a natural tolerance to egg protein produce more of an anti-inflammatory protein, providing a potential biomarker to differentiate previously-allergic patients from children who still have the allergy.
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Potential Therapy Found for Incurable Pediatric Brain Tumor
Northwestern Medicine scientists have discovered a new potential drug therapy for pediatric brainstem glioma by targeting a genetic mutation found in patients with the rare, incurable cancer.
