Category: Disease Discoveries
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Cancer Genes Turned Off in Deadly Brain Cancer
Northwestern Medicine scientists have identified a small RNA molecule called miR-182 that can suppress cancer-causing genes in mice with glioblastoma mulitforme (GBM) when delivered using spherical nucleic acid nanoparticles.
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White Matter Plays Big Role in Brain Injury Recovery
A new Northwestern Medicine study reveals that white matter loss is associated with impaired verbal abilities, an important implication for cognitive recovery following traumatic brain injury.
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‘Phenomapping’ Categorizes Heart Failure to Tailor Therapies
Northwestern Medicine scientists used “big data” tools to classify for the first time three distinct categories of a common heart failure syndrome. The findings may be used to better predict how diverse patients will respond to treatments.
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Targeting Growth Factor Improves Skin Cancer Therapies
A Northwestern Medicine study found that standard treatments for metastatic melanoma are not effective against Nodal, a growth factor protein critical for the skin cancer’s development, but also showed that combination therapies incorporating anti-Nodal antibodies are a promising alternative.
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Exploring Bacterial Competition in Reproductive Tract Infections
Northwestern Medicine scientists have shown that the bacteria that cause gonorrhea may have evolved mechanisms to stimulate white blood cells into killing other bacteria, promoting the survival of gonorrhea bacteria in the human reproductive tract.
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Uncovering Genetic Roots of Pediatric Kidney Tumor
A Northwestern Medicine study has identified new genetic mutations in patients with Wilms tumor, the most common kidney tumor in children.
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Alzheimer Amyloid Clumps Found in Young Adult Brains
A Northwestern medicine study found accumulations of amyloid in young adult brains, the first time accumulation of amyloid has been shown at such a young age.
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DNA Transcription Sheds Light on Cancer Pathogenesis
In several recent publications, Ali Shilatifard, PhD, chair of Biochemistry and Molecular Genetics, examined how different aspects of transcriptional regulation are involved in cancer development.
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Exploring Age-Related Differences in Herpes Encephalitis
Northwestern Medicine scientists have revealed age-dependent differences in cellular mechanisms for protection from herpes simplex virus encephalitis.
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Auditory Pain Pathway May Protect Against Hearing Loss
Northwestern Medicine scientists have discovered a novel pain pathway in the inner ear that warns of dangerously loud noise and may act as a “bodyguard” for the ears, protecting against hearing loss.
