Category: Disease Discoveries
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Study Reveals Molecular Mechanisms Behind Genetic Kidney Disease
A Northwestern Medicine study has uncovered the molecular mechanisms behind the development of autosomal dominant polycystic kidney disease (ADPKD) and a potential drug target.
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Specialized Immune Cells May Improve Early Detection of Parkinson’s Disease
An elevated presence of specialized immune cells were found in patients prior to developing motor symptoms and receiving a diagnosis of Parkinson’s disease, which may help improve early detection.
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Cancer Cells Hijack Nucleotide Metabolism to Boost Cell Proliferation
Mutations in the genes RAS and RAF allow cancer cells to create their own nucleotides, fueling cancer growth, according to a recent study published in Molecular Cell.
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Mechanism Behind Upper Motor Neuron Degeneration Revealed
Scientists from Northwestern Medicine and the University of Belgrade have pinpointed the electrophysiological mechanism behind upper motor neuron disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
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Origin of Cancer Cells Influences Skin Cancer Prognosis
A new Northwestern Medicine study found important differences in rare skin lymphomas stemming from their specific cell of origin and clinical presentations, according to findings published in Nature Communications.
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High Blood Pressure Associated with Cognitive Decline in African American Patients
Higher cumulative blood pressure among African-American patients is a major contributor to their higher risk of dementia, according to a new study.
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Genetic ‘Neighborhoods’ Fuel Leukemia
A new study has found that genetic alterations in a rare form of leukemia physically change the architecture of DNA, fueling the replication and spread of cancer cells.
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Chronic Bronchitis Damages Lung Function
Adults with chronic cough and phlegm production are at risk for poor respiratory function, even if they don’t have more severe respiratory disorders, according to a new study.
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Using Genomics to Understand the Severity of Bacterial Infections
Northwestern Medicine investigators have uncovered a novel pathogenic mechanism used by the bacterium Pseudomonas aeruginosa to promote more severe infections.
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Elevated Gene Expression Linked to Poor Glioblastoma Survival
The elevated expression of a gene called LY6K was correlated with increased cancer cell growth and resistance to radiation therapy in glioblastoma, according to a recent Northwestern Medicine study.
