Category: Disease Discoveries
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Lewy Body Dementia Exacerbated by Immune Response
T-cells respond to buildup of alpha-synuclein with a harmful auto-immune response, according to a Northwestern Medicine study published in Science.
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Machine-learning Model Can Detect Rare Cardiomyopathy
A machine learning model can identify patients at risk of a rare cardiomyopathy, according to a recent study.
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Northwestern Scientists Explore Impacts of Genomic Variation in Disease in NIH Project
Northwestern is part of the Impact of Genomic Variation on Function (IGVF) Consortium, a $185 million National Institutes of Health (NIH) project that will explore the millions of genetic variants that cause disease around the world.
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Skin Cancer Harbors Targetable Mutation
An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in the JAK-STAT pathway, according to a recent Northwestern Medicine study.
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Translational Science: Glioblastoma
Northwestern’s Brain Tumor SPORE — part of the Lurie Cancer Center — is now three years old, and the bench to bedside process is producing results.
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Improving Immune Response Against Viral Infections and Disease
Blocking an inhibitory pathway within a subset of specialized T-cells may improve overall immune response against virally driven cancers, according to findings published in Nature.
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Revising Theory of Cancer-Induced Immune Suppression
Many cancers produce an enzyme called IDO that suppresses immune system activity, but the long-held hypothesis of how this mechanism operates requires revision, according to a Northwestern Medicine study.
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Some Chemotherapy Side Effects Could Be Prevented
Harmful side effects from a common chemotherapy drug could be prevented in patients with a specific mutation by targeting retinoic acid receptors, according to a recent study.
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New Genetic Mutations Linked to Neurodevelopmental Disease
Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder.
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Surface Protein Helps Tumor Cells Form Clusters
Circulating tumor cells use the surface protein ICAM1 to strengthen stem cell programs and facilitate formation of tumor cell clusters, which can travel from primary tumors to other organs in the body.
