Category: Disease Discoveries
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Mechanisms of Antibody Production May Help Improve Vaccines
Northwestern scientists have discovered how IgA antibodies are produced through unexpected cellular pathways, findings that may help inform the design of more effective vaccines to prevent infections, according to a recent study.
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Study Finds Uneven Burden of Brain and Nervous System Cancers in the US
A new nationwide study has revealed striking differences in how brain and nervous system cancers affect Americans depending on where they live, as well as their age, sex and socioeconomic status, according to the study published in JAMA Neurology.
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Genetic Mechanisms Promote Antimicrobial Resistance in Gonorrhea
Northwestern Medicine scientists have identified previously unknown genetic mechanisms that promote antimicrobial resistance in gonorrhea, findings that may inform the development of more effective treatment strategies, according to a recent study published in PLoS Pathogens.
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How a Cellular ‘Engine’ Controls Building Blocks of DNA
Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in Molecular Cell.
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Genetic Testing Trifecta Predicts Risk of Sudden Cardiac Death and Arrhythmia
Scientists have developed a more precise genetic risk score to determine whether a person is likely to develop arrhythmia, which can lead to serious conditions such as atrial fibrillation or sudden cardiac death.
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Targeting Cardiovascular Aging to Reduce Disease Risk
Northwestern Medicine scientists have uncovered new insights into how the PAI-1 protein contributes to cardiovascular aging and how inhibiting PAI-1 may be a promising therapeutic approach for mitigating cardiovascular disease, according to recent findings published in The Journal of Clinical Investigation.
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New Antibody Therapy Reawakens Immune System to Fight Pancreatic Cancer
A new study shows that pancreatic tumors use a sugar-based disguise to hide from the immune system, and Northwestern scientists have also created an antibody therapy that blocks the “don’t-attack” signal.
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A New Clue to ALS and FTD: Faulty Protein Disrupts Brain’s ‘Brake’ System
A new Northwestern study has uncovered how a key disease protein drives overactive nerve cells in neurodegenerative diseases like ALS and frontotemporal dementia.
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Study Identifies Gene Linked to Rare Ciliopathy Disorders
A Northwestern Medicine-led study has identified mutations in the gene CEP76 as a new cause of ciliopathies, shedding light on a complex group of disorders that affect multiple body systems, according to a study published in Science Advances.
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Transcription Factor Drives Chemotherapy Resistance in Ovarian Cancer
Northwestern Medicine scientists have discovered how a specific transcription factor promotes genetic reprogramming and chemotherapy resistance in ovarian cancer cells, findings that may inform new targeted treatment approaches that inhibit this process and improve patient outcomes, according to a recent study published in The Journal of Clinical Investigation.
