Category: Disease Discoveries
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Shape-Shifting Cell Channel Reveals New Target for Precision Drugs
In a new study published in Nature Communications, Northwestern scientists have uncovered how a critical membrane pathway controls the flow of chemical messages responsible for everything from brain activity to inflammation.
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NU-9 Halts Alzheimer’s Disease In Animal Model Before Symptoms Begin
In a new study, scientists have identified a previously unknown driver of Alzheimer’s disease, and an experimental drug developed at Northwestern University has demonstrated further promise as an early intervention to treat the disease.
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Common Virus ‘Rewires’ Intracellular Mechanisms to Promote Infection
Investigators from the laboratory of Derek Walsh, PhD, have discovered how human cytomegalovirus rewires intracellular mechanisms to control the movement of the cell nucleus and promote infection, according to a recent study.
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RNA ‘Quality Control’ System Breaks Down in ALS
A Northwestern Medicine study has shed light on a critical molecular mechanism underlying amyotrophic lateral sclerosis (ALS), according to findings published in the journal Neuron.
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Mechanisms of Antibody Production May Help Improve Vaccines
Northwestern scientists have discovered how IgA antibodies are produced through unexpected cellular pathways, findings that may help inform the design of more effective vaccines to prevent infections, according to a recent study.
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Study Finds Uneven Burden of Brain and Nervous System Cancers in the US
A new nationwide study has revealed striking differences in how brain and nervous system cancers affect Americans depending on where they live, as well as their age, sex and socioeconomic status, according to the study published in JAMA Neurology.
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Genetic Mechanisms Promote Antimicrobial Resistance in Gonorrhea
Northwestern Medicine scientists have identified previously unknown genetic mechanisms that promote antimicrobial resistance in gonorrhea, findings that may inform the development of more effective treatment strategies, according to a recent study published in PLoS Pathogens.
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How a Cellular ‘Engine’ Controls Building Blocks of DNA
Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in Molecular Cell.
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Genetic Testing Trifecta Predicts Risk of Sudden Cardiac Death and Arrhythmia
Scientists have developed a more precise genetic risk score to determine whether a person is likely to develop arrhythmia, which can lead to serious conditions such as atrial fibrillation or sudden cardiac death.
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Targeting Cardiovascular Aging to Reduce Disease Risk
Northwestern Medicine scientists have uncovered new insights into how the PAI-1 protein contributes to cardiovascular aging and how inhibiting PAI-1 may be a promising therapeutic approach for mitigating cardiovascular disease, according to recent findings published in The Journal of Clinical Investigation.
