Category: Clinical Breakthroughs
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Investigators Discover New Therapeutic Target for Pediatric Brain Cancers
Northwestern Medicine investigators have discovered that targeting the TIM3 protein in mouse models of low-grade astrocytoma increased survival compared to current immunotherapies, according to recent findings published in the Journal of Clinical Investigation.
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‘Dancing Molecules’ Heal Cartilage Damage
A new therapeutic strategy developed by Northwestern investigators activated the gene expression necessary to regenerate cartilage growth within just four hours, according to findings from a recent study.
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Improving Risk Prediction in Pregnancy-related Hypertensive Disorders
Proteomic analysis of blood samples from pregnant individuals did not improve risk prediction of hypertensive disorders of pregnancy compared to current methods, underscoring the demand for more accurate prediction tools, according to findings published in JAMA Cardiology.
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Study Evaluates Treatment Interventions for Severe Obesity in Adolescents
Adolescents with severe obesity who received meal replacement therapy plus financial incentives experienced a greater reduction in body mass index compared to those who received meal replacement therapy alone, according to recent findings published in JAMA Pediatrics.
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Exploring CAR T-cell Therapy for Aggressive Follicular Lymphoma
CAR T-cell therapy is an effective treatment for aggressive subtypes of follicular lymphoma, according to a clinical trial published in Nature Medicine.
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Subcutaneous Therapy Improves Inflammatory Bowel Disease Treatment
Subcutaneous delivery of an anti-TNF inhibitor therapy improved remission rates compared to placebo in patients with moderate-to-severe Crohn’s disease and ulcerative colitis who previously completed intravenous anti-TNF therapy, according to clinical trial results published in the journal Gastroenterology.
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Combination Therapy May Improve Outcomes for Advanced Bladder Cancer
Patients with immunotherapy-resistant bladder cancer who received a novel combination treatment demonstrated improved response to treatment, according to a recent study published in Nature Medicine.
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Improving Advanced Care Planning for Late-Stage Cancer
Multilevel care interventions improved clinician–documented advanced care planning compared with a clinician-level intervention alone for patients with genitourinary cancer, according to recent findings published in JAMA Oncology.
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Common Blood Pressure Drug May Increase Risk of Bleeding
People with irregular heartbeats taking a common blood pressure drug may be at greater risk of serious bleeding, according to a study recently published in JAMA.
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Drug Reprograms Immune Responses to Target Glioblastoma
Investigators have discovered that using a novel drug agonist to target the STING pathway in preclinical models of glioblastoma reprogrammed previously suppressed immune responses, according to recent findings published in the Journal of Clinical Investigation.
