Byline: Melissa Rohman
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Study Identifies Novel Regulators of Hippocampal Overactivity
Reduced expression of specific calcium channels impaired electrical signaling between neurons and contributed to the onset of behaviors associated with neurodevelopmental disorders and seizure susceptibility in mouse models, according to a Northwestern Medicine study.
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Study Identifies New Mechanisms Driving Genomic Instability
A recent Northwestern Medicine study has identified new mechanisms that cause genomic or chromosomal instability during cell division, findings that may improve the development of biomarkers and targeted therapies for cancer.
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New Therapeutic Target for Osteoarthritis Identified
Investigators have discovered that a subset of sensory neurons promote osteoarthritis-related joint pain and inflammation, suggesting a new therapeutic target for pain management, according to findings published in Nature Communications.
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Biological Aging Increases Risk of Depression, Anxiety in Adults
Advanced biological aging may increase the risk of depression or anxiety in midlife for older adults, according to a recent study published in Nature Communications.
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Newly Discovered Mechanisms Increase Chemotherapy Resistance in Breast Cancer
Northwestern Medicine investigators have discovered novel features of circulating tumor stem cells that can promote chemotherapy evasion and metastasis in triple-negative breast cancer, according to a recent study.
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Transcription Factor Prevents Bone Frailty in Chronic Kidney Disease
Northwestern Medicine investigators have discovered that the overexpression of a specific transcription factor prevented bone loss in mouse models with complications from chronic kidney disease, according to a recent study published in the Journal of Clinical Investigation.
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Study Establishes Fluctuating ’Gating’ Mechanisms Supporting Flexible Behavior
A study led by Elizabeth Johnson, PhD, has established fluctuating “gating” mechanisms that support flexible behavior and working memory in humans, findings recently published in Nature Communications.
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Genetic Mutation Responsible for Rare Neurodevelopmental Disorder Identified
Using zebrafish models, investigators have discovered that MAP4K4 genetic variants cause neurodevelopmental delays and other physical abnormalities, demonstrating a potential therapeutic target for treating the disorder in humans, according to findings published in Science Advances.
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Study Reveals Striking Excess Deaths for Black Americans Over Last 20 Years
From 1999 through 2020, Black Americans experienced more than 1.6 million excess deaths and more than 80 million excess years of life lost compared to white Americans, according to a recent study published in JAMA.
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Investigators Identify Mechanisms Behind Chemotherapy Resistance
A team led by Northwestern Medicine investigators have discovered novel cellular mechanisms that lead to chemotherapy resistance in recurrent glioblastoma, according to findings published in Science Advances.
