Byline: Melissa Rohman
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Newly Discovered Mechanisms Increase Chemotherapy Resistance in Breast Cancer
Northwestern Medicine investigators have discovered novel features of circulating tumor stem cells that can promote chemotherapy evasion and metastasis in triple-negative breast cancer, according to a recent study.
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Transcription Factor Prevents Bone Frailty in Chronic Kidney Disease
Northwestern Medicine investigators have discovered that the overexpression of a specific transcription factor prevented bone loss in mouse models with complications from chronic kidney disease, according to a recent study published in the Journal of Clinical Investigation.
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Study Establishes Fluctuating ’Gating’ Mechanisms Supporting Flexible Behavior
A study led by Elizabeth Johnson, PhD, has established fluctuating “gating” mechanisms that support flexible behavior and working memory in humans, findings recently published in Nature Communications.
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Genetic Mutation Responsible for Rare Neurodevelopmental Disorder Identified
Using zebrafish models, investigators have discovered that MAP4K4 genetic variants cause neurodevelopmental delays and other physical abnormalities, demonstrating a potential therapeutic target for treating the disorder in humans, according to findings published in Science Advances.
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Study Reveals Striking Excess Deaths for Black Americans Over Last 20 Years
From 1999 through 2020, Black Americans experienced more than 1.6 million excess deaths and more than 80 million excess years of life lost compared to white Americans, according to a recent study published in JAMA.
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Investigators Identify Mechanisms Behind Chemotherapy Resistance
A team led by Northwestern Medicine investigators have discovered novel cellular mechanisms that lead to chemotherapy resistance in recurrent glioblastoma, according to findings published in Science Advances.
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Honors Day Celebrates Student and Faculty Excellence
Faculty members and fourth-year medical students were recognized for their academic and clinical excellence during Feinberg’s Honors Day, held May 12 in the Hughes auditorium.
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Increasing Early Cardiovascular Screenings for Dilated Cardiomyopathy
An informational communications tool provided to patients with dilated cardiomyopathy helped increase cardiovascular screenings in their first-degree relatives who have a higher risk of developing the genetic disease, according to findings published in Circulation.
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Improving the Study of Sex-Based Differences in Complex Traits and Disease
Investigators led by Barbara Stranger, PhD, associate professor of Pharmacology, developed a guide outlining best practices for studying and testing sex-dependent genetic effects in complex traits and diseases, published in the journal Cell.
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Bioengineered Protein May Prevent COVID Infections and Improve Survival
A novel protein developed by Northwestern Medicine investigators improved survival and prevented brain infection in mice infected with SARS-CoV-2 when administered intranasally, according to a recent study.
