Feinberg
Northwestern Medicine | Northwestern University | Faculty Profiles

News Center

  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Releases
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Menu
  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Releases
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Home » Study Investigates Crosstalk Between Mitochondria and Lysosomes
Scientific Advances

Study Investigates Crosstalk Between Mitochondria and Lysosomes

By Melissa RohmanOct 25, 2022
Share
Facebook Twitter Email
Dimitri Krainc headshot
Dimitri Krainc, MD, chair and the Aaron Montgomery Ward Professor of the Ken and Ruth Davee Department of Neurology, was senior author of the study published in the Journal of Cell Biology.

Investigators have discovered that outer mitochondrial membrane proteins regulate crosstalk between mitochondria and lysosomes, according to a Northwestern Medicine study published in the Journal of Cell Biology. These findings have implications for the role of organelle networks in cellular homeostasis and the development of neurological diseases.

“This study further elucidates the mechanism underlying mitochondrial and lysosomal crosstalk and shows how different mutations in the same mitochondrial protein can result in distinct downstream defects in lysosomal network dynamics that contribute to different neurological disorders,” said Dimitri Krainc, MD, the Aaron Montgomery Ward Professor and chairman of the Ken and Ruth Davee Department of Neurology.

Lysosomes are organelles tasked with breaking down excess or unusable parts of the cell. Elucidating the regulation of lysosomal networks is key to understanding of cellular dynamics and the role of lysosomes in disease pathogenesis.  

In a prior work published in Nature, Krainc’s team discovered direct contacts between mitochondria and lysosomes. In the current study, the investigators used live super-resolution microscopy to discover that lysosomes frequently tether together into lysosomal clusters at inter-lysosomal contact sites — sites which modulate lysosomal distribution and function — and subsequently untether, rather than fuse together.

 Yvette Wong, PhD, assistant professor in the Ken and Ruth Davee Department of Neurology’s Division of Movement Disorders, was lead author of the study.

They also found that mitochondria, the energy powerhouses of the cell, promote this untethering, which is influenced by the hydrolysis of the enzyme Rab7-GTP at inter-lysosomal contact sites. Additionally, they showed that mitochondrial proteins Mid51 and Fis1 form an oligomeric protein complex on mitochondria that, in turn, drives Rab7-GTP hydrolysis and the untethering of lysosomes.

Overall, the study demonstrates how different mutations in Mid51 that are linked to specific neurological disorders result in distinct downstream defects in lysosomal network dynamics. 

“A dominant optic atrophy-associated Mid51 mutant which does not disrupt its oligomerization does not disrupt lysosomal network dynamics. In contrast, a Mid51 mutant potentially linked to Parkinson’s disease which misregulates its oligomerization disrupts this pathway, resulting in defective lysosomal network dynamics,” said Yvette Wong, PhD, assistant professor in the Ken and Ruth Davee Department of Neurology’s Division of Movement Disorders and lead author of the study.

PingPing Song, PhD, research assistant professor of Neurology in the Division of Movement Disorders, and Steven Lubbe, PhD, assistant professor of Neurology in the Division of Movement Disorders, were co-authors of the study.

This work was supported by National Institutes of Health National Institute of Neurological Disorders and Stroke grants F32 NS101778, K99 NS109252, R00 NS109252, R01 NS076054, R37 NS096241 and National Institute of Neurological Disorders and Stroke Diversity Research Supplement 3R00NS109252-03S1.

Neurology Neurology and Neuroscience Research
Share. Facebook Twitter Email

Related Posts

Sex-Specific Mechanisms for Major Depressive Disorder Identified in Response to Dysregulated Stress Hormones

Mar 23, 2023

Pre-Surgery Immunotherapy May Increase Survival in Advanced Melanoma

Mar 23, 2023

Hormone Therapy Plus Current Treatments Improves Survival in Prostate Cancer

Mar 22, 2023

Comments are closed.

Latest News

Sex-Specific Mechanisms for Major Depressive Disorder Identified in Response to Dysregulated Stress Hormones

Mar 23, 2023

Pre-Surgery Immunotherapy May Increase Survival in Advanced Melanoma

Mar 23, 2023

Hormone Therapy Plus Current Treatments Improves Survival in Prostate Cancer

Mar 22, 2023

How ChatGPT Has, and Will Continue to, Transform Scientific Research

Mar 21, 2023

New Directions for HIV Treatment

Mar 21, 2023
  • News Center Home
  • Categories
  • Press Release
  • Media Coverage
  • Editor’s Picks
  • News Archives
  • About Us
Flickr Photos
20230317_NM651
20230317_NM610
20230317_NM569
20230317_NM537
20230317_NM331
20230317_NM323
20230317_NM316
20230317_NM336
20230317_NM626
20230317_NM662
20230317_NM655
20230317_NM642

Northwestern University logo

Northwestern University Feinberg School of Medicine

RSS Facebook Twitter LinkedIn Flickr YouTube Instagram
Copyright © 2023 Northwestern University
  • Contact Northwestern University
  • Disclaimer
  • Campus Emergency Information
  • Policy Statements

Type above and press Enter to search. Press Esc to cancel.