Feinberg
Northwestern Medicine | Northwestern University | Faculty Profiles

News Center

  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Releases
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Menu
  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Releases
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Home » Alzheimer’s Drug Shows Promise, But Risk Remains
Disease Discoveries

Alzheimer’s Drug Shows Promise, But Risk Remains

By Will DossOct 12, 2018
Share
Facebook Twitter Email
A normal mossy fiber pathway (left) compared to a shortened, disorganized pathway caused by BACE1 inhibition (right).

An experimental genetic inhibitor that could stave off Alzheimer’s disease has unintended consequences, but may represent a target for future drug development, according to a study published in Science Translational Medicine.

A new strategy to inhibit BACE1, an enzyme that makes a protein involved in Alzheimer’s disease, improves on previous iterations but also causes new defects in the hippocampus, said Robert Vassar, PhD, professor in The Ken & Ruth Davee Department of Neurology and senior author of the study.

“You don’t want to create a new disease when you are trying to cure another one,” said Vassar, who is also scientific director of the Division of Behavioral Neurology, a professor of Cell and Molecular Biology and principal investigator of the Alzheimer’s Disease Core Center grant. “I think the BACE1 inhibitors are going to be important for prevention, but this concern has to be dealt with.”

Alzheimer’s disease has two major physical characteristics in the brain: buildup of amyloid plaques and aggregates of tau proteins known as neurofibrillary tangles. While it’s still unknown exactly how these cause cognitive symptoms, it’s known that the amyloid accumulates first, irritating brain tissue not unlike a sliver, according to Vassar.

“If you get many slivers in your foot and you don’t take care of them, it’s going to get infected, have inflammation and before you know it, you’re going to lose the leg,” Vassar said. “The amyloid proteins don’t kill neurons by themselves, but they eventually lead to something bad.”

In a previous investigation, Vassar discovered a gene heavily involved in amyloid production: BACE1. Early trials of BACE1 inhibitors in animal models of Alzheimer’s disease showed a reduction in amyloid proteins, but depriving these models of BACE1 from birth created other issues, according to Vassar.

Robert Vassar, PhD, professor in The Ken & Ruth Davee Department of Neurology, scientific director of the Division of Behavioral Neurology, principal investigator of the Alzheimer’s Disease Core Center grant and a professor of Cell and Molecular Biology.

“The wiring in the hippocampus was disorganized and they didn’t learn memory tasks very well,” Vassar said. “We discovered BACE1 was important for the developing brain, so to truly investigate BACE1 we would have to let the mouse grow up, grow old and then knock it out.”

In the current study, Vassar and his colleagues did just that, deleting the BACE1 gene in adult mice using a timed, site-specific genetic editing technology that functions like genetic scissors.

“You can feed the mouse Tamoxifen, an estrogen-like drug, and it will activate the scissors and chop out the exon you are targeting,” Vassar said.

Mice who had BACE1 deleted once they had reached maturity exhibited fewer of the problems when compared to the mice that were missing BACE1 from birth, according to the study.

“For example, a protein called neuregulin requires BACE1 in order to do its job during development,” Vassar said. “But in the adult, BACE1 cleavage of neuregulin is not entirely necessary, so these mice survive fine without it.”

However, the investigators discovered the adult mice had deformations in the mossy fiber pathway, a structure in the hippocampus important for memory. This is concerning with several clinical trials of BACE1 inhibitors either in-progress or on the horizon, Vassar said, but all is not lost.

The current study inhibited BACE1 almost entirely: 90 to 95 percent inhibition. Vassar believes there might still be a sweet spot of inhibition: low enough to keep the mossy fiber pathway intact while still high enough to significantly decrease amyloid protein production.

“I want to try and find out at what level of inhibition this occurs,” Vassar said.  “I think if you can fine-tune it and start early enough, you can have a huge impact.”

While there’s currently no quick clinical test, identifying patients with elevated amyloid counts and prescribing them a BACE1 inhibitor is a promising strategy for preventing Alzheimer’s disease, according to Vassar.

“Current estimates show that if you could delay the onset of Alzheimer’s disease by five years, you will have cured half of it, because the patients are often elderly and die from other causes,” Vassar said. “The patients and their families will have a much better quality of life, and I’m hopeful we will eventually get there.”

Other Northwestern authors include Ming-Husan Ou-Yang, postdoctoral fellow in the Vassar laboratory and first author of the study; Jelena Popovic, technical staff in the Vassar laboratory; Jonathan Kurz, MD, PhD, ’15 GME, instructor of Pediatrics in the Division of Neurology and Epilepsy; Anis Contractor, PhD, professor of Physiology; Toshihiro Nomura, postdoctoral fellow in the Contractor laboratory; Hongxin Dong, MD, PhD, associate professor of Psychiatry and Behavioral Sciences; Dane Chetkovich, MD, PhD, adjunct professor of Neurology in the division of Neurophysiology/Epilepsy and Warren Tourtellotte, MD, PhD, adjunct professor of Pathology.

This work was supported by National Institutes of Health grant R01 AG022560, K26 OD010945 and K02-NS046468, the BrightFocus Foundation and the Baila Foundation.

Cell and Developmental Biology Genetics Neurology and Neuroscience Research
Share. Facebook Twitter Email

Related Posts

Sex-Specific Mechanisms for Major Depressive Disorder Identified in Response to Dysregulated Stress Hormones

Mar 23, 2023

Pre-Surgery Immunotherapy May Increase Survival in Advanced Melanoma

Mar 23, 2023

Hormone Therapy Plus Current Treatments Improves Survival in Prostate Cancer

Mar 22, 2023

Comments are closed.

Latest News

Sex-Specific Mechanisms for Major Depressive Disorder Identified in Response to Dysregulated Stress Hormones

Mar 23, 2023

Pre-Surgery Immunotherapy May Increase Survival in Advanced Melanoma

Mar 23, 2023

Hormone Therapy Plus Current Treatments Improves Survival in Prostate Cancer

Mar 22, 2023

How ChatGPT Has, and Will Continue to, Transform Scientific Research

Mar 21, 2023

New Directions for HIV Treatment

Mar 21, 2023
  • News Center Home
  • Categories
  • Press Release
  • Media Coverage
  • Editor’s Picks
  • News Archives
  • About Us
Flickr Photos
20230317_NM651
20230317_NM610
20230317_NM569
20230317_NM537
20230317_NM331
20230317_NM323
20230317_NM316
20230317_NM336
20230317_NM626
20230317_NM662
20230317_NM655
20230317_NM642

Northwestern University logo

Northwestern University Feinberg School of Medicine

RSS Facebook Twitter LinkedIn Flickr YouTube Instagram
Copyright © 2023 Northwestern University
  • Contact Northwestern University
  • Disclaimer
  • Campus Emergency Information
  • Policy Statements

Type above and press Enter to search. Press Esc to cancel.