Tag: Genetics
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Cilia Defects Linked to Schizophrenia
Mutations in PCM1, a gene involved in the formation of cilia, were linked with schizophrenia in a variety of animal models and in human genome analysis, according to a recent study.
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New Path Forward for Pancreatic Cancer Treatment
Combining the current standard-of-care chemotherapy drug with a genetic inhibitor may improve treatment for pancreatic ductal adenocarcinoma, according to a recent study published in PNAS.
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Unusual Epigenetic Regulator Could Impact Cancer
A newly discovered function of an epigenetic regulator could be a key to new cancer treatments, according to a new study published in Genes and Development.
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Using Stem Cells for Drug Discovery
A group of scientists combined medicinal chemistry and human stem cells to improve a medication treating a cardiac rhythm disorder, a strategy that could be applied broadly.
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Source of Rare Intellectual Disability Syndrome Discovered
New findings have revealed previously unknown information about the genetic basis for Armfield XLID syndrome, a rare intellectual disability linked to genetic defects in the X chromosome.
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New Details on T-Cell Methylation
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
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New Chemotherapy Alternative for Lymphoma
A new immunotherapy treatment for recurrent B-cell lymphoma was found to be safe in a trial of nearly 350 patients, according to a study published in The Lancet.
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New Drug Target for Treatment-Resistant Prostate Cancer
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
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Biological Sex Affects Genes for Body Fat, Cancer, Birth Weight
Biological sex has a small but ubiquitous influence on gene expression in almost every type of human tissue, according to a new study.
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Gene Therapy Could Treat Atrial Fibrillation
Targeting oxidative stress with a genetic therapy reduced atrial fibrillation in animal models of disease, making this a promising future treatment, according to a study published in Circulation.
