Tag: Genetics
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How Cells Defend Against Influenza A Virus
Human cells use a protein named TBC1D5 to “trap and kill” influenza A viruses inside host cells, but the virus encodes its own protein to disable this defense.
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Anti-Cancer Inhibitor Could Have Dual Effect
TG2, an enzyme known to help cancers spread more quickly, also plays a role in regulating T-cells — opening the door to dual inhibition, according to a recent Northwestern Medicine study.
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Northwestern Scientists Explore Impacts of Genomic Variation in Disease in NIH Project
Northwestern is part of the Impact of Genomic Variation on Function (IGVF) Consortium, a $185 million National Institutes of Health (NIH) project that will explore the millions of genetic variants that cause disease around the world.
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Skin Cancer Harbors Targetable Mutation
An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in the JAK-STAT pathway, according to a recent Northwestern Medicine study.
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Excitatory Neural Receptors Aid Development of Adult-born Neurons
A unique interaction between an excitatory neural receptor and a chloride transporter are critical for development of adult-born neurons in the dentate gyrus.
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Translational Science: Glioblastoma
Northwestern’s Brain Tumor SPORE — part of the Lurie Cancer Center — is now three years old, and the bench to bedside process is producing results.
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Some Chemotherapy Side Effects Could Be Prevented
Harmful side effects from a common chemotherapy drug could be prevented in patients with a specific mutation by targeting retinoic acid receptors, according to a recent study.
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New Genetic Mutations Linked to Neurodevelopmental Disease
Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder.
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Transcription Elongation Checkpoint Discovered
Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template.
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Genomic Autopsy Identifies Cardiomyopathy Variants
Genomic autopsy of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy.
