Browsing: Cell and Developmental Biology

A recent Northwestern Medicine study has identified new mechanisms that cause genomic or chromosomal instability during cell division, findings that may improve the development of biomarkers and targeted therapies for cancer.

Using zebrafish models, investigators have discovered that MAP4K4 genetic variants cause neurodevelopmental delays and other physical abnormalities, demonstrating a potential therapeutic target for treating the disorder in humans, according to findings published in Science Advances. 

Northwestern Medicine scientists have uncovered a mechanism by which exercise activates metabolic benefits in the body, according to a new study published in Cell Metabolism.

Northwestern Medicine scientists have identified pathogenic variants in two genes linked to microcephaly and other neurodevelopmental disorders in children, according to a recent study published in Nature Communications.

Styliani (Stella) Markoulaki, PhD, has been named the new director of the Transgenic and Targeted Mutagenesis Laboratory.

Investigators identified a molecular “brake” that can reduce the activation of damaging cells known to cause primary graft dysfunction — a leading culprit in lung transplant failure.

A Northwestern Medicine study has uncovered distinct roles of major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics.

Investigators have discovered that two cytoskeletal proteins which were previously thought to function independently actually interact and form essential cytoskeletal networks within the cell surface.

Motor proteins “slingshot” microtubules within developing egg cells of fruit flies, creating a current that transports mRNA to a developing egg.

A previously unknown mechanism involving the protein Scribble helps maintain polarity in cells, according to a Northwestern Medicine study.