Tag: Biochemistry and Molecular Genetics
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Leukemia Hijacks Nucleotide Metabolism
T-cell acute lymphoblastic leukemia hijacks a signaling pathway to produce nucleotides, a basic building block of life that fuels the growth and spread of the cancer, according to a recent study.
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Uncovering How Protein Complexes Impact Gene Expression
Northwestern Medicine scientists have detailed the diverse function of CDK9-containing complexes and their impact on gene expression in a recent study published in the journal Genes and Development.
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Streamlining Chemical-Genetic Screening
Northwestern Medicine scientists have developed a new high-throughput sequencing tool to test how drugs interact with genetically modified cells.
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Discovering New Mechanisms in Epigenetics
A series of recent discoveries by Northwestern Medicine scientists point to a more nuanced understanding of how epigenetic regulators function.
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Mitochondria-Targeted Antioxidants Inhibit Tumor Growth
Northwestern Medicine investigators have discovered that inserting dietary antioxidants into the mitochondria of cancer cells may inhibit overall tumor growth.
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Scientists Unravel Zebrafish Epigenome
A new Northwestern Medicine study has identified tissue-specific epigenetic regulators in zebrafish, filling in a longtime gap in the understanding of the organism’s genome.
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Unusual Epigenetic Regulator Could Impact Cancer
A newly discovered function of an epigenetic regulator could be a key to new cancer treatments, according to a new study published in Genes and Development.
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New Details on T-Cell Methylation
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
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New Drug Target for Treatment-Resistant Prostate Cancer
Inhibiting an epigenetic regulator called DOT1L could be a key to slowing treatment-resistant prostate cancer, according to a recent Northwestern Medicine study.
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Understanding Mitochondrial Dysfunction’s Impact on Neurological Diseases
A recent Northwestern Medicine study may improve the understanding of mitochondrial dysfunction and its impact on the development of neurological diseases.
