Tag: Biochemistry and Molecular Genetics
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New Method to Analyze Nucleosomes
Northwestern Medicine scientists have developed Nuc-MS, a new method to capture the protein composition of whole nucleosomes without losing information.
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Understanding Epigenetic Regulators in Neurodevelopmental Diseases and Cancer
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
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Inhibiting SAM Biosynthesis to Slow Tumor Growth
Inhibiting production of a key material produced by the mTOR pathway could slow tumor growth, according to a recent Northwestern Medicine study.
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Next-Gen Sequencing
Northwestern’s investment in next-generation sequencing is leading to unprecedented avenues of discovery.
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Leukemia Hijacks Nucleotide Metabolism
T-cell acute lymphoblastic leukemia hijacks a signaling pathway to produce nucleotides, a basic building block of life that fuels the growth and spread of the cancer, according to a recent study.
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Uncovering How Protein Complexes Impact Gene Expression
Northwestern Medicine scientists have detailed the diverse function of CDK9-containing complexes and their impact on gene expression in a recent study published in the journal Genes and Development.
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Streamlining Chemical-Genetic Screening
Northwestern Medicine scientists have developed a new high-throughput sequencing tool to test how drugs interact with genetically modified cells.
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Discovering New Mechanisms in Epigenetics
A series of recent discoveries by Northwestern Medicine scientists point to a more nuanced understanding of how epigenetic regulators function.
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Mitochondria-Targeted Antioxidants Inhibit Tumor Growth
Northwestern Medicine investigators have discovered that inserting dietary antioxidants into the mitochondria of cancer cells may inhibit overall tumor growth.
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Scientists Unravel Zebrafish Epigenome
A new Northwestern Medicine study has identified tissue-specific epigenetic regulators in zebrafish, filling in a longtime gap in the understanding of the organism’s genome.
