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Overlooked DNA Structures Help Organize the Genome
Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published in the Proceedings of the National Academy of Sciences.
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Novel Synthetic Biomolecule Degrades Disease-Related Proteins
Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can target and degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study.
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NUCATS and NICO Symposium Sparks Interdisciplinary Collaboration
Recently, the Symposium to Empower High-Priority Research Collaborations, organized by the Northwestern University Clinical and Translational Sciences Institute and the Northwestern Institute on Complex Systems, focused on addressing critical challenges in human health and disease through team-based approaches.
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Study Uncovers Potential Gene Therapy for Late-Stage Parkinson’s Side-Effects
Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of neurons in the brain may reverse levodopa-induced dyskinesia in patients with late-stage Parkinson’s disease without reducing the symptomatic benefits of levodopa treatment, according to a recent study published in Neuron.
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Alzheimer Day Highlights Research Advances and Community Engagement
Faculty, clinicians, investigators and community members gathered on May 19 for Alzheimer Day, an annual conference dedicated to advancing understanding of dementia and connecting cutting-edge research with patients and families.
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Asthma Drug Improves Treatment of Aggressive Cancers in Preclinical Studies
A drug widely used to treat asthma and allergies may also help fight aggressive cancers, reports a new Northwestern Medicine study that uncovered how tumors hijack common white blood cells to evade immunotherapy.
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Wearable Polygraph Detects Hidden Stress
Northwestern University engineers have developed a small, wireless polygraph system you can wear, designed to sense underlying stress hidden deep within the body.
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‘Toxic’ Molecule Plays Vital Role in Gene Regulation and Development
A molecule once thought to be a harmful metabolic byproduct may play a crucial role in early development and gene regulation, according to a new study published in Nature that challenges decades of biochemical assumptions.
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Policing Plagiarism of Ideas in Generative AI-Assisted Research Writing
A new publication argues that AI-assisted plagiarism in manuscript writing harms the research environment by eroding trust among scientists, misrepresenting the origin and authenticity of scholarly work, and discouraging innovation and original inquiry.
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Feinberg Students Launch Inaugural Day of Service Across Chicago
Students from across Northwestern University Feinberg School of Medicine’s academic programs came together on Sunday, May 3, for the inaugural Feinberg Day of Service — a new student-led initiative centered on volunteerism, community partnership and cross-program connection.
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Linking Lysosomal Dysfunction to Severe Neurological Disorders
A new study has identified mutations in a single gene as the cause of a previously unrecognized spectrum of severe neurological disorders, according to a study published in the Journal of Clinical Investigation.
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New Experimental Method Reveals Protein Energy Landscapes on Larger Scale
Northwestern Medicine scientists have developed a new experimental method to analyze conformational fluctuations in protein domains on a uniquely large scale, which may improve data-driven modeling, biology and protein engineering, as detailed in a recent study published in Nature.
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Spatial Transcriptomics Guides Inflammatory Bowel Disease Research
A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the development of inflammatory bowel diseases, as detailed in a recent study published in Nature Communications.
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Honors Day Celebrates Medical School Excellence
Fourth-year medical students and faculty members were recognized for academic and clinical excellence during Feinberg’s Honors Day, held on May 15 in the Hughes Auditorium.
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Honoring the MD Class of 2026
Feinberg honored the MD Class of 2026 during this year’s commencement ceremony held in the Aon Grand Ballroom at Navy Pier on May 18.
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Building Capacity for Research in Ukraine
Two Feinberg investigators, Sara Huston, MS, and Steven P. Cohen, MD, have been collaborating with scientists in Ukraine to better understand how war is impacting Ukrainians through inquiries into DNA use for family reunification and better treating amputees’ pain.
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Skin-Resident Immune Cells Drive Neuropathic Pain in Diabetes
In experimental models of diabetes, Northwestern Medicine scientists have discovered that a specialized group of skin-resident immune cells drive neuropathic pain through sex-dependent signaling pathways, according to a recent study published in The Journal of Clinical Investigation.
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Understanding Treatment Response in High-Risk Bladder Cancer
A new study may pave the way toward more personalized treatments for patients with high-risk bladder cancer, according to a study published in European Urology.
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ALS is Driven by a Domino‑Like Chain Reaction That Begins in Nerve Cells
A new Northwestern Medicine study provides evidence that ALS unfolds through a domino‑like sequence of events that begins with an early breakdown inside motor neurons and is followed by a damaging inflammatory response.
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Metformin Slows Mitochondrial Energy Production, Promotes Glycemic Control
A new Northwestern Medicine study has found that metformin, a commonly prescribed diabetes drug, focuses primarily on the gut, acting to prevent glucose levels rising in the blood by driving glucose utilization inside cells lining the intestine.