Glioblastoma is an aggressive brain tumor that affects an estimated 12,000 people per year, with poor overall prognosis and long-term survival rates. Northwestern Medicine scientists are at the forefront of leading-edge investigations to discover the roots of glioblastoma’s origins, and to pinpoint innovative new treatments to attack this deadly disease.
Glioblastoma
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Tumor Mutations Predict Response to Immunotherapy
A recent Northwestern Medicine study found that patients with glioblastoma responded better or worse to immunotherapy depending on the presence of certain mutations in their tumors.
New Role for Dopamine in Deadly Brain Cancer
A Northwestern Medicine study has demonstrated the role of dopamine in the progression of glioblastoma and suggests that targeting the neurotransmitter may slow cancer growth.
New Gene Associated With Glioblastoma Discovered
Northwestern Medicine scientists have identified a gene, called isocitrate dehydrogenase 3-alpha, that promotes tumors in grade IV glioblastoma, according to a study published in Science Advances.
Brain Tumor SPORE Drives Rapid Translation
Northwestern Medicine investigators are leading a Specialized Program of Research Excellence (SPORE) in brain cancer with a special emphasis on glioblastoma.
Enzyme Blocker Stops Growth of Deadly Brain Tumor
Scientists discovered the regulatory role of the enzyme CDK5 in an aggressive form of brain cancer and successfully halted tumor growth by inhibiting it.
Glioblastoma Survival Mechanism Reveals New Therapeutic Target
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation therapy.
Novel Screening Method Reveals Glioblastoma Drug Target
Scientists used a new approach to identify a promising therapeutic target for glioblastoma, which was previously overlooked in traditional approaches.
Nanomedicine Opens Door to Precision Medicine for Brain Tumors
Early phase Northwestern Medicine research has demonstrated a potential new therapeutic strategy for treating glioblastoma.
PhD Student Explores Enzyme’s Role in Aggressive Brain Tumor
Northwestern Medicine scientists have demonstrated that an enzyme called IDH1 plays a significant role in cancer progression and may be a target for novel drug therapies.
Cold Virus, Stem Cells Tested to Destroy Deadly Brain Cancer
An investigational neural stem cell therapy that works with a common cold virus to seek out and attack malignant glioma is being tested at Northwestern Medicine in a phase I clinical trial.