Category: Scientific Advances
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Cells ‘Switch’ on Protein Factories After Injury, Study Finds
Scientists have uncovered a novel mechanism through which skin cells organize and control protein production during homeostasis and wound healing, according to a new study published in Developmental Cell.
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Targeting Novel Long Non-Coding RNA May Improve Glioblastoma Treatment
Scientists have discovered that increased expression of a novel long non-coding RNA drives glioblastoma cell growth alongside a genetic amplification found in more than half of glioblastoma tumors, according to a Northwestern Medicine study published in Nature Cell Biology.
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Transcription Factors Form Continuous ‘Circuit’ That Regulates T-cell Exhaustion
Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion and migration during viral infection, which may inform future therapeutic strategies for managing infections and cancer, according to a recent Northwestern Medicine study.
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Uncovering Cellular Drivers of Increased Brain Signal Activity
Northwestern Medicine scientists have discovered new insights into how high gamma activity, a widely studied brain signal, is generated, findings that can impact how past and future neurological studies using this signal are interpreted, according to a recent study published in Nature.
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Study Identifies New Molecular Mechanisms Supporting Cell Adhesion
Scientists led by Sergey Troyanovsky, PhD, professor of Dermatology and of Cell and Developmental Biology, have uncovered new intracellular mechanisms promoting cell-cell adhesion, a process disrupted in a variety of skin and inflammatory diseases, according to a recent study published in the Journal of Cell Biology.
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Light Impacts How the Brain Perceives and Remembers Threats
Northwestern Medicine scientists have discovered that light plays a key role in how animals perceive environmental threats, findings that could improve the understanding of risk avoidance behaviors and disorders in humans, according to a recent study published in Nature Communications.
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Calcium Signaling Channels Regulate Neuroinflammation and Motivation
Northwestern Medicine scientists have discovered how calcium signaling channels in the brain’s immune cells regulate neuroinflammation and promote the development of behaviors associated with affective mood disorders, according to a recent study published in Science Signaling.
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Trashing Cancer’s ‘Undruggable’ Proteins
Northwestern scientists have developed polymers capable of grabbing proteins and directing them to the cell’s waste-disposal machinery, potentially triggering cancer cell death.
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Targeting Cellular Mechanisms May Improve Immune Response in Chronic Infections
Northwestern Medicine scientists have identified cellular mechanisms that cause immune cells to differentiate and ultimately lose function during viral infection, findings that could improve therapeutic strategies for controlling chronic infection, according to a recent study.
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AI Model May Improve RNA Sequencing Research
Scientists in the laboratory of Rendong Yang, PhD, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications.
