3-D Structure of COMPASS Protein Complex Revealed
The three-dimensional atomic structure of the epigenetic driver COMPASS was solved for the first time in a study published in the journal Cell.
Browsing: Scientific Advances
Motor Protein Organizes Egg Development
A motor protein called kinesin drives a unique mechanism that ensures correct placement of important proteins and mRNA during development of egg cells.
Mapping Dopamine Neuron Projections
In a study published in Nature Neuroscience, Northwestern Medicine scientists demonstrated that subtypes of dopamine neurons have distinct projection patterns.
Stimulation Excites the Brain to Form Better Memories
For the first time, scientists were able to specifically change the way the brain’s memory centers form new memories, according to a new Northwestern Medicine study.
Mechanisms Driving Inherited Heart Disease
Northwestern Medicine scientists have identified a novel mechanism for how mutations in desmoplakin — a protein that helps cells stick together — can lead to cardiac arrhythmias and other diseases.
Exploring the Mechanisms of Poxvirus Replication
A study published in the journal Cell uncovers how poxviruses take control of a protein complex in order to enhance their replication and counteract an immune response in hosts.
Long Non-Coding RNA May Play Role in Fat Metabolism
A team of scientists has identified thousands of lincRNAs — long non-coding RNA molecules produced by so-called “junk DNA” — that are unique to human fat cells and may play an important role in fat metabolism.
Mapping Calcium Channels Provides New Insights into Disease
Northwestern Medicine scientists have discovered the activation mechanism of a calcium channel, providing new insights for future drug development targeting this calcium signaling pathway.
Understanding the Epigenetics of Sex Determination
A team of scientists has identified a key enhancer of Sox9 — a gene critical for male sex development — and demonstrated that deleting the enhancer results in male-to-female sex reversal in animal models.
Increased Cell Recycling Could Treat Aging-Related Conditions
Enhancing autophagy, the system that recycles old or dysfunctional cells, could have therapeutic effects in a variety of aging-related diseases, according to a pair of Northwestern Medicine studies.