Identifying New Targeted Therapy Approaches for Leukemia
Using small molecular inhibitors to block the BAP1 complex may be a promising targeted therapy approach for leukemia, according to a Northwestern Medicine study published in Nature Cancer.
Browsing: Scientific Advances
New Method to Analyze Nucleosomes
Northwestern Medicine scientists have developed Nuc-MS, a new method to capture the protein composition of whole nucleosomes without losing information.
Uncovering Epigenetic Mechanisms Underlying Cancer Development
Two Northwestern Medicine studies are improving the understanding of epigenetic mechanisms in cancer development and progression, and identifying novel cancer driver genes that may help identify patients who will benefit from immunotherapy.
Mitochondria Play Key Role in Lymphatic Development
Mitochondria play a key role in forming the lymphatic vasculature by acting as a metabolic sensor during the migration of lymphatic progenitor cells from the veins.
Mitochondria Could Boost Immunotherapy Effectiveness
Boosting mitochondrial function in a subpopulation of T cells could make cancer immunotherapy more effective, according to a recent study.
Understanding Epigenetic Regulators in Neurodevelopmental Diseases and Cancer
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
Next-Gen Sequencing
Northwestern’s investment in next-generation sequencing is leading to unprecedented avenues of discovery.
Identifying Molecular Mechanisms Within the Nuclear Lamina
Northwestern Medicine investigators discovered that nuclear surface proteins called nuclear lamin isoforms regulate nuclear pore complexes, shedding light on the role molecular mechanisms play in genetic mutations behind many rare diseases.
Inhibiting Protein Degradation May Prevent Cocaine-Induced Reward Behaviors
Northwestern Medicine investigators have discovered that inhibiting a specific autophagy protein found in dopaminergic neurons may prevent reward-related behaviors induced by cocaine misuse.
Uncovering How Protein Complexes Impact Gene Expression
Northwestern Medicine scientists have detailed the diverse function of CDK9-containing complexes and their impact on gene expression in a recent study published in the journal Genes and Development.