Category: Disease Discoveries
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Revising Theory of Cancer-Induced Immune Suppression
Many cancers produce an enzyme called IDO that suppresses immune system activity, but the long-held hypothesis of how this mechanism operates requires revision, according to a Northwestern Medicine study.
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Some Chemotherapy Side Effects Could Be Prevented
Harmful side effects from a common chemotherapy drug could be prevented in patients with a specific mutation by targeting retinoic acid receptors, according to a recent study.
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New Genetic Mutations Linked to Neurodevelopmental Disease
Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder.
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Surface Protein Helps Tumor Cells Form Clusters
Circulating tumor cells use the surface protein ICAM1 to strengthen stem cell programs and facilitate formation of tumor cell clusters, which can travel from primary tumors to other organs in the body.
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Brain Insult From Hypertension Discovered in Middle-Aged Adults
Hypertension that leads to vascular dementia in older adults begins to impact the brain by middle age, according to a new study, the first to show the process beginning so early.
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New Hope for Antibody to Treat Muscular Dystrophy
Northwestern Medicine scientists have developed an antibody that they believe can be used to treat muscular dystrophy, reducing muscle scarring in an animal model of the disease.
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Biomarker Predicts Cognitive Decline in Alzheimer’s Disease
A biomarker in the brain predicts future cognitive decline in patients with the language form of Alzheimer’s disease (AD), reports a new Northwestern Medicine study.
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Investigating COVID-19: Vaccine Effectiveness, Mechanisms of Infection and Child Hospitalization
Northwestern Medicine scientists continue to investigate all aspects of the COVID-19 pandemic: from molecular mechanisms of infection, to child hospitalization and single-dose vaccine response.
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Uncovering Epigenetic Mechanisms Regulating Glioma Growth
Northwestern Medicine investigators have discovered the epigenetic mechanisms involved in the regulation of two oncogenes in glioma cells, which may improve personalized approaches to treat these cancers.
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Fluorescent Label Passes Through Blood-Brain Barrier
Fluorescent indocarbocyanine lipid labels show improved distribution within glioblastoma brain tumors, according to a Northwestern Medicine study.
