A recent study from the laboratory of Shi-Yuan Cheng, PhD, has identified novel mechanisms underlying RNA splicing events within glioma tumor cells, mechanisms which may serve as novel therapeutic targets, according to findings published in The Journal of Clinical Investigation.
A unique genetic variation in the MAPT gene was associated with increased risk of Pick’s disease, a rare form of frontotemporal dementia, according to a recent study published in The Lancet Neurology.
A team of Northwestern Medicine investigators has discovered novel DNA methylation patterns in the blood of patients with Parkinson’s disease, findings that demonstrate the potential for using DNA methylation as a biomarker to identify the disease.
Northwestern Medicine investigators led by Amy Heimberger, MD, PhD, have discovered a new mechanism in which cancer-associated fibroblasts are associated with tumor grade and mediate immune suppression in glioma tumors.
Thrombolytic therapy administered longer after the onset of ischemic stroke than current recommendations did not demonstrate improved clinical outcomes as compared to placebo, according to a recent trial published in the New England Journal of Medicine.
A new study has found the immune system in the blood of Alzheimer’s patients is epigenetically altered, and many of these altered genes are the same ones that increase an individual’s risk for Alzheimer’s.
An experimental drug designed to block blood-clotting proteins may slightly lower the risk of recurrent strokes, according to a dose-finding trial published in The Lancet Neurology.
A new Northwestern Medicine study has identified short strands of toxic RNAs that contribute to brain cell death and DNA damage in Alzheimer’s and aged brains.
Northwestern Medicine investigators have discovered that specialized immune cells within the glioblastoma tumor microenvironment use a unique “feeding” mechanism that promotes tumor growth and treatment resistance, according to findings published in the journal Cell Metabolism.
An established transcription factor known for bone formation also supports specialized cells in the central nervous system to promote brain tissue stiffness, findings that could inform new therapeutics for neuronal regeneration, according to a Northwestern Medicine study published in Neuron.
