Northwestern Medicine investigators have discovered a novel protein region that regulates DNA transcription elongation, suggesting a new therapeutic target for treating cancers and developmental disorders, according to findings published in Molecular Cell.
Epigenetic aging could serve as a promising biomarker for measuring long-term cardiovascular health and disease risk, according to a recent Northwestern Medicine study.
Two Northwestern Medicine studies are improving the understanding of epigenetic mechanisms in cancer development and progression, and identifying novel cancer driver genes that may help identify patients who will benefit from immunotherapy.
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
Northwestern Medicine investigators have discovered that oncogenes contain specific epigenetic markers called broad genic repression domains, which could help identify potential therapeutic targets for cancer treatment.
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
A new $15 million gift from University trustees and supporters Louis A. Simpson and Kimberly K. Querrey will establish the Simpson Querrey Institute for Epigenetics at Northwestern University Feinberg School of Medicine, boosting the school’s current efforts to study the effects of environment on the regulation of gene expression.
Using mathematical modeling and optical imaging they developed themselves, a Northwestern University research team has discovered how chromatin folds at the single-cell level.
The Simpson Querrey Center for Epigenetics is connecting the Northwestern academic and medical community to integrate the study of epigenetics into science and clinical care.
Targeting cancer cells with a transcription elongation inhibitor delayed tumor progression in animal models, according to a recent Northwestern Medicine study.