Tag: Epigenetics
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Study Discovers Novel Region for BRD4 Transcription and Potential Therapeutic Target
Northwestern Medicine investigators have discovered a novel protein region that regulates DNA transcription elongation, suggesting a new therapeutic target for treating cancers and developmental disorders, according to findings published in Molecular Cell.
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Exploring Epigenetic Aging and Cardiovascular Disease Risk
Epigenetic aging could serve as a promising biomarker for measuring long-term cardiovascular health and disease risk, according to a recent Northwestern Medicine study.
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Uncovering Epigenetic Mechanisms Underlying Cancer Development
Two Northwestern Medicine studies are improving the understanding of epigenetic mechanisms in cancer development and progression, and identifying novel cancer driver genes that may help identify patients who will benefit from immunotherapy.
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Understanding Epigenetic Regulators in Neurodevelopmental Diseases and Cancer
Northwestern Medicine investigators are advancing the understanding of two groups of transcription factors and their role in many neurodevelopmental diseases and cancers, which is essential for developing novel therapeutic approaches.
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Identifying Oncogenes through Epigenetic Markers
Northwestern Medicine investigators have discovered that oncogenes contain specific epigenetic markers called broad genic repression domains, which could help identify potential therapeutic targets for cancer treatment.
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New Details on T-Cell Methylation
The DNA methylation landscape of regulatory T-cells is more complex than previously understood, according to a new Northwestern Medicine study.
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Gift Names Epigenetics Institute at Feinberg
A new $15 million gift from University trustees and supporters Louis A. Simpson and Kimberly K. Querrey will establish the Simpson Querrey Institute for Epigenetics at Northwestern University Feinberg School of Medicine, boosting the school’s current efforts to study the effects of environment on the regulation of gene expression.
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Chromatin Organizes Itself Into 3D ‘Forests’ in Single Cells
Using mathematical modeling and optical imaging they developed themselves, a Northwestern University research team has discovered how chromatin folds at the single-cell level.
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Epigenetics: Landscape of Disease
The Simpson Querrey Center for Epigenetics is connecting the Northwestern academic and medical community to integrate the study of epigenetics into science and clinical care.
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Disrupting Gene Transcription Elongation to Treat Cancer
Targeting cancer cells with a transcription elongation inhibitor delayed tumor progression in animal models, according to a recent Northwestern Medicine study.
