Tag: Biochemistry and Molecular Genetics
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Understanding Cellular Transcription Responses to Oxygen Deprivation
A multiprotein complex is essential for regulating cellular transcription response to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.
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Trailblazing Biochemist Delivers Kimberly Prize Lecture
Influential biochemist Craig M. Crews, PhD, who pioneered the pharmaceutical field of targeted protein degradation, delivered the second Kimberly Prize in Biochemistry and Molecular Genetics Lecture to a full auditorium of Feinberg faculty, staff, fellows and students.
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Potential Therapeutic Target for Small Cell Lung Cancer Discovered
Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer cells may decrease cancer cell differentiation and tumor growth, according to findings published in Nature Communications.
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Novel Biological Mechanism Discovered That Could Lead to New Treatments for Neurological Disorders, Cancers
The lab of Yongchao C. Ma, PhD, has discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.
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Novel Role for Metabolites in Cellular Metabolism Discovered
Investigators led by Issam Ben-Sahra, PhD, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used by cells to make DNA and RNA, according to a recent study published in Science.
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New 3D Spatial Approach Reveals Interactive View of Glioblastoma and Therapeutic Targets
A multidisciplinary team of investigators has developed a first-of-its-kind interactive 3D spatial approach that reveals new therapeutic targets and provides a comprehensive three-dimensional view of glioblastoma tumors, detailed in a recent study published in Cell.
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Localized Genetic Mutations May Serve as Biomarker for Wide Range of Cancers
Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.
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Pioneering Biochemist Craig Crews Named Winner of 2024 Kimberly Prize
Northwestern University Feinberg School of Medicine and the Simpson Querrey Institute for Epigenetics announced today that renowned biochemist Craig M. Crews, PhD, who pioneered the pharmaceutical field of targeted protein degradation, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.
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New Human Gene Cluster Sequence Discovered
Investigators from the laboratory of Ali Shilatifard, PhD, have discovered a new repeat gene cluster sequence that is exclusively expressed in humans and non-human primates, according to findings published in Science Advances.
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Pioneering Automated Proteoform Imaging
Investigators led by Neil Kelleher, PhD, have developed an automated technique for imaging proteoforms in ovarian cancer, according to results published in Nature Communications.
