Category: Disease Discoveries
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Potential Therapeutic Target for Small Cell Lung Cancer Discovered
Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer cells may decrease cancer cell differentiation and tumor growth, according to findings published in Nature Communications.
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Novel Mechanism Supports Antitumor Response and T-cell Survival
A recent Northwestern Medicine study has discovered a previously unknown molecular mechanism that supports antitumor responses and cell survival in cytotoxic immune cells, according to findings published in the Journal of Clinical Investigation.
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Investigating Mechanisms of Aggressive Glioblastoma Tumor Growth
Northwestern Medicine investigators have identified a metabolism-related gene that may play a role in recruiting immune cells to support the growth of aggressive brain tumors, according to a study recently published in Nature Communications.
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Study Explores Characteristics Associated with Poor COVID-19 Antibody Response
U.S. adults with certain socio-demographic and clinical characteristics may have weaker antibody responses to COVID-19 vaccination, according to a recent study published in Nature Communications.
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Novel Immune Inhibitor Associated with Glioma Progression
Northwestern Medicine investigators led by Amy Heimberger, MD, PhD, have discovered a new mechanism in which cancer-associated fibroblasts are associated with tumor grade and mediate immune suppression in glioma tumors.
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Study Uncovers Novel Mechanisms Behind Food Allergies
A recent Northwestern Medicine study sheds light on the mechanisms of a specific protein that is necessary for the production of IgA antibodies in the gut in response to food allergens, according to findings published in the journal Mucosal Immunology.
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New Genes Implicated in Uterine Fibroid Development
Northwestern Medicine scientists have identified new genes implicated in the development of uterine fibroids, according to a study published in Nature Communications.
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Release of Inhibitory Pathways May Promote Immune Response to HIV
Recent work from the laboratory of Elena Martinelli, PhD, MPH, has discovered how inhibiting an immune cell singling pathway in a model of HIV-1 infection may promote immune responses and decrease viral persistence in conjunction with antiretroviral therapy.
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Innate Immune Cells Promote Growth of Blood Vessels in Colon Cancer
A type of white blood cell is responsible for growth and branching of blood vessels which supports tumor growth in colon cancer, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
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Outsmarting Chemo-Resistant Ovarian Cancer
Northwestern Medicine scientists have discovered the Achilles heel of chemotherapy-resistant ovarian cancer — its hunger for cholesterol — and how to sneakily use that to destroy it.
