Category: Disease Discoveries
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Addressing Racial and Ethnic Disparities in COVID-19 Hospitalizations, Outcomes
Overall mortality for patients hospitalized for COVID-19 in the U.S. during the first half of 2020 was 18.4 percent, with more than half of all deaths occurring in Black and Hispanic patients, according to findings published in the journal Circulation.
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New Developments in Parkinson’s Pathology
The strength of neuron-to-neuron connections does not govern the spread of Parkinson’s disease in the brain, according to a recent study.
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Proxy Measures Fail to Assess Cardiovascular Care
Using proxy measures of preparedness for hypertension or diabetes care did not accurately assess the ability of low- and middle-income countries to treat patients, according to a study published in PLOS Medicine.
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Exploring the Relationship Between Inflammation and Heart Failure
The presence of inflammatory proteins was associated with comorbidity burden and deteriorating heart function in patients with heart failure with preserved ejection fraction, according to a Northwestern Medicine study.
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Cilia Defects Linked to Schizophrenia
Mutations in PCM1, a gene involved in the formation of cilia, were linked with schizophrenia in a variety of animal models and in human genome analysis, according to a recent study.
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Uncovering the Impact of Protein Mutations in Parkinson’s
Northwestern scientists have determined how two protein mutations responsible for the impaired motor function in Parkinson’s disease independently disrupt neuron activity.
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New Path Forward for Pancreatic Cancer Treatment
Combining the current standard-of-care chemotherapy drug with a genetic inhibitor may improve treatment for pancreatic ductal adenocarcinoma, according to a recent study published in PNAS.
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Investigating the Biology of Aging
Feinberg investigators are breaking down the mechanisms of aging and designing solutions to extend healthy living.
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McNally Discusses COVID-19 Antibody Study Results, Next Steps
During a recent webinar, Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine, discussed findings from the ongoing Screening for Coronavirus Antibodies in Neighborhoods (SCAN) study and what genetics can reveal about COVID-19.
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Viral Protein Rewires B-Cells to Promote Infection
A viral protein of the Epstein-Barr virus previously thought to mimic immune cell receptor signaling actually rewires intracellular signaling in infected cells, promoting viral cell survival and proliferation.
