Category: Clinical Breakthroughs
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Combination Therapy Does Not Extend Survival in Glioblastoma
Patients with a subtype of glioblastoma who received a combination treatment of a PARP inhibitor and standard chemotherapy did not demonstrate improved survival compared to chemotherapy and placebo, according to a recent clinical trial published in JAMA Oncology.
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Study Finds Sustained Remission of Obesity-related Conditions a Decade After Adolescent Weight Loss Surgery
Ten years after undergoing bariatric surgery as teens, over half of study participants demonstrated not only sustained weight loss, but also resolution of obesity-related conditions, such as type 2 diabetes, high blood pressure and high cholesterol.
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Improving Atopic Dermatitis Treatment for Adolescents
Long-term treatment with the drug upadacitinib significantly improved symptoms and quality of life compared to placebo in adolescents with moderate to severe atopic dermatitis after 76 weeks with strong evidence of safety, according to a recent Northwestern Medicine analysis of three international, randomized clinical trials.
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Scientists Develop Approach to Accurately Predict Pneumonia Outcomes
By applying a sophisticated machine-learning approach to electronic health records of patients with pneumonia, investigators at Northwestern University have uncovered five distinct clinical states in pneumonia.
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Chronic Pain Can Be Predicted Within Three Days of an Injury
Within a few days of injury, scientists can predict which patients will develop chronic pain based on the extent of cross “talk” between two regions of the brain, and the person’s anxiety level after the injury, according to a new Northwestern study.
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Implant Could Prevent Opioid Overdose Deaths
A team of scientists led by Northwestern Medicine investigators has created an implant capable of stopping an opioid overdose, according to findings published in Science Advances.
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More Inpatient Beds Needed to Address Youth Mental Health Crisis
The number of pediatric inpatient psychiatric beds has not risen to meet demand amid a growing youth mental health crisis, according to a Northwestern Medicine-led study published in JAMA Pediatrics.
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Thrombectomy Does Not Improve Outcomes for Patients with Large Strokes
Treatment with endovascular thrombectomy did not significantly improve outcomes after 90 days in patients with a large core stroke, as compared to patients who received standard stroke care alone, according to a recent clinical trial published in JAMA.
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Delayed Antibody Treatment May Improve Efficacy of mRNA Vaccines
Investigators led by Pablo Penaloza-MacMaster, PhD, associate professor of Microbiology-Immunology, have discovered that administering an antibody treatment four days after mRNA vaccination significantly improved vaccine efficacy in mice, according to findings published in The Journal of Clinical Investigation.
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Novel Blood Test Predicts Risk of Severe Lung Disease
Northwestern Medicine investigators have created a novel blood test that identifies adults who may be at increased risk of developing severe respiratory illnesses, according to a recent study published in the American Journal of Respiratory and Critical Care Medicine.
