Byline: Melissa Rohman
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Combination Treatment May Slow Disease Progression in Advanced Sarcoma
An oral combination treatment may prevent disease progression in patients with advanced leiomyosarcoma, one of the most common subtypes of soft tissue sarcoma, according to a recent study published in The Lancet Oncology.
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AI Model May Improve RNA Sequencing Research
Scientists in the laboratory of Rendong Yang, PhD, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications.
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Identifying Mechanisms Supporting Nanoparticle Therapy for Autoimmune Diseases
Northwestern Medicine scientists in the laboratory of Stephen Miller, PhD, have identified the cellular and molecular mechanisms required for the antigen-specific tolerance inducing abilities of a novel nanoparticle therapy for treating autoimmune diseases, according to a recent study published in Science Advances.
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Non-invasive Approach Predicts Chemotherapy Response in Glioblastoma
Northwestern Medicine scientists have developed a new non-invasive approach that could help better determine which patients with glioblastoma are responding favorably to chemotherapy treatment and inform future treatment plans, according to a recent study published in Nature Communications.
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Evaluating Treatment of Heart Defects in Preterm Infants
Early pharmacologic treatment of a common congenital heart defect did not improve survival outcomes compared to expectant management in preterm infants, according to a recent clinical trial published in JAMA.
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New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve Targeted Therapies
Northwestern Medicine scientists have discovered new mechanisms underlying transcriptional initiation and elongation control that support proper gene expression, which may inform targeted therapeutic approaches for many diseases, according to a recent study published in Molecular Cell.
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Novel Mechanism Regulates Essential Enzyme Production in Kidneys
Scientists have discovered previously unknown cellular mechanisms that regulate the production of renin, an essential enzyme in the kidney, findings that could improve the understanding of how the kidney regulates its function and how chronic kidney disease develops, according to a recent study published in Cell.
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Hypervigilance, Anxiety Linked to Poor Treatment Outcomes in Esophageal Disorder
Increased esophageal hypervigilance and anxiety were associated with worse post-treatment symptoms and poor quality of life in patients with achalasia, a rare esophageal motility disorder, according to a recent Northwestern Medicine study.
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Targeting Aberrant Learning May Improve Parkinson’s Treatment
Northwestern Medicine scientists have discovered that targeting neuronal signaling controlling aberrant learning in the striatum may improve the efficacy of a first-line therapy for Parkinson’s disease and has the potential to reduce therapy-related side effects, according to a recent study published in Science Advances.
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2025 in Scientific Imagery
From elucidating cellular mechanisms underlying tissue regeneration to developing novel biomaterials to improve organ function, Feinberg investigators have provided stunning new snapshots of biological processes invisible to the naked eye.
