Patients with cancer of the skin’s oil glands on eye or body will have better care
It starts as a yellow or shiny bump on the eyelids, face or body that grows and doesn’t go away, unlike a pimple.
The bump is sebaceous carcinoma, a cancer of the oil glands diagnosed in thousands of patients in the U.S. every year. If not removed and treated promptly, it can spread to other organs and cause grave harm to patients, including death. But up until now there was no commonly agreed method to treat it.
A new Northwestern Medicine study published in The Lancet Oncology reports the first guidelines for treating this rare tumor, which required expertise from both dermatologists and ophthalmologists, because it can be on the skin as well as in the eyes.
“Now there is a clear direction for treating these tumors, which may result in fewer tumors spreading to other organs and fewer deaths,” said Murad Alam, MD, vice chair and professor of Dermatology and a Northwestern Medicine dermatologist.
“With limited resources to develop guidelines, rare tumors often get neglected,”said Alam, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. “It’s also more challenging to develop guidelines for rare tumors because there is less data in the medical literature about these.”
The guidelines tell physicians how to best perform biopsies to find (or exclude) sebaceous carcinoma. They also explain physicians need to treat eyelid and non-eyelid sebaceous carcinoma differently. The surgical approaches described in the guidelines enable removal of sebaceous carcinoma with a high rate of cure without risking injury to important organs, like the eyes.
Having a sebaceous carcinoma can be a helpful clue that the same patient has undetected Muir-Torre Syndrome, which increases the risk for colon cancer. When a sebaceous carcinoma is found in a patient, the guidelines explain whether and how the patient should also be checked for Muir-Torre Syndrome. If they have Muir-Torre, then they can be screened for colon cancer.
Northwestern Medicine has a particular expertise in the treatment of less common skin cancers. It is the lead coordinating site for several international collaborations in this area, notably the Committee on Invasive Skin Tumor Evidence-Based Recommendations, an international working group of specialists at major academic medical centers who develop tools (like guidelines) to better treat rare and uncommon skin cancers.
