Feinberg
Northwestern Medicine | Northwestern University | Faculty Profiles

News Center

  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Release
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Menu
  • Categories
    • Campus News
    • Disease Discoveries
    • Clinical Breakthroughs
    • Education News
    • Scientific Advances
  • Press Release
  • Media Coverage
  • Podcasts
  • Editor’s Picks
    • COVID-19
    • Cardiology
    • Cancer
    • Neurology and Neuroscience
    • Aging and Longevity
    • Artificial Intelligence in Medicine
  • News Archives
  • About Us
    • Media Contact
    • Share Your News
    • News Feeds
    • Social Media
    • Contact Us
Home » Molecular Mechanisms Regulating Prostate Cancer Hypoxia Identified
Disease Discoveries

Molecular Mechanisms Regulating Prostate Cancer Hypoxia Identified

By Melissa RohmanSep 2, 2022
Share
Facebook Twitter Email
Jindan Yu, MD, PhD, professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, was senior author of the study published in Oncogene.

A Northwestern Medicine study has identified a molecular mechanism that helps regulate the progression of castration-resistant prostate cancer, according to findings published in the journal Oncogene.

Investigators led by Jindan Yu, MD, PhD, professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, discovered that the downregulation of the protein FOXA1 regulates hypoxia, or lack of oxygen, in prostate cancer tumors and promotes tumor progression.

“The function of FOXA1 in inhibiting lineage plasticity is important because it is the metastasis and drug resistance of castration-resistant prostate cancer that kills the patient,” Yu said.  

Lourdes Brea, a fourth-year student in the Driskill Graduate Program in Life Sciences (DGP), was co-first author of the study.

Prostate cancer is the second-leading cause of cancer-related mortality among men in the U.S. While treatment options such as radiation and hormone therapy are available and effective in treating early-stage cancer, many patients develop treatment resistance and progress to metastatic castration-resistant prostate cancer (CRPC).

Current treatment options for CRPC offer limited benefit for patients and few studies have investigated the molecular mechanisms of hypoxia underlying CRPC progression, which is crucial for developing effective targeted therapies.

Recent work from the Yu laboratory and others discovered that FOXA1 becomes down-regulated in prostate cancer metastasis, suggesting that FOXA1 may play a tumor-suppressive role in CRPC.

In the current study, Yu and collaborators aimed to determine whether FOXA1 down-regulation controls hypoxic programming in the prostate tumor microenvironment and contributes to cancer progression.

Lourdes Brea, a fourth-year student in the Driskill Graduate Program in Life Sciences (DGP), was co-first author of the study.

By performing in vitro analysis of prostate cancer cell lines, the investigators discovered that FOXA1 binds to the protein HIF1A, inhibiting its expression. In turn, HIF1A helps regulate hypoxia gene expression induced by FOXA1 loss.

Additionally, through HIF1A, FOXA1 down-regulation promotes the infiltration of macrophages into the tumor microenvironment, which helps the tumor become immunosuppressive and increases prostate cancer cell invasion.

“When macrophages are recruited into the tumor, they can actually antagonize T-cell function and impair immune response, which is bad,” Yu said.

The findings point to FOXA1 as a key player in regulating hypoxic tumor microenvironments in CRPC and overall promotion of prostate cancer progression. Now, Yu’s team is investigating FOXA1’s role in regulating immune response in in vivo models of prostate cancer. 

“We respectively disagree with people in the field suggesting to therapeutically target FOXA1, because it may lead to lineage plasticity, hypoxia and CRPC progression. We think you should really target epithelial-mesenchymal transition and hypoxia programs that are caused by FOXA1 loss to prevent or treat CRPC,” Yu said.

Jonathan Zhao, MD, MS, associate professor of Medicine in the Division of Hematology and Oncology, was a co-author of the study.

Yu and Zhao are members of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

This work was supported in part by the National Institutes of Health (NIH) prostate SPORE P50CA180995, NIH grant R50CA211271 and Prostate Cancer Foundation grant 2017CHAL2008.

Biochemistry and Molecular Genetics Cancer Medicine Research
Share. Facebook Twitter Email

Related Posts

Shortage of Mental Health Professionals Linked to Increase in Youth Suicides

Jan 25, 2023

Understanding How Childhood Brain Tumors Develop

Jan 23, 2023

Medical School Establishes New Center for Psychiatric Neuroscience

Jan 19, 2023

Comments are closed.

Latest News

Changes in Medical School Leadership

Jan 26, 2023

Shortage of Mental Health Professionals Linked to Increase in Youth Suicides

Jan 25, 2023

Northwestern Medicine Scholars Program Inspires a New Generation of Physicians and Scientists 

Jan 24, 2023

Understanding How Childhood Brain Tumors Develop

Jan 23, 2023

Medical School Establishes New Center for Psychiatric Neuroscience

Jan 19, 2023
  • News Center Home
  • Categories
  • Press Release
  • Media Coverage
  • Editor’s Picks
  • News Archives
  • About Us
Flickr Photos
Feinberg_In_Vivo_20221209_tcrawford-24
Feinberg_In_Vivo_20221209_tcrawford-16
Feinberg_In_Vivo_20221209_tcrawford-14
Feinberg_In_Vivo_20221209_tcrawford-5
Feinberg_In_Vivo_20221209_tcrawford-6
Feinberg_In_Vivo_20221209_tcrawford-10
Feinberg_In_Vivo_20221209_tcrawford-8
Feinberg_In_Vivo_20221209_tcrawford-18
Feinberg_In_Vivo_20221209_tcrawford
Feinberg_In_Vivo_20221209_tcrawford-23
Feinberg_In_Vivo_20221209_tcrawford-25
Feinberg_In_Vivo_20221209_tcrawford-26

Northwestern University logo

Northwestern University Feinberg School of Medicine

RSS Facebook Twitter LinkedIn Flickr YouTube Instagram
Copyright © 2023 Northwestern University
  • Contact Northwestern University
  • Disclaimer
  • Campus Emergency Information
  • Policy Statements

Type above and press Enter to search. Press Esc to cancel.