A team of scientists has demonstrated a novel approach to delivering cancer drugs directly to tumor cells, through gold nanoparticles that can be remotely triggered to release therapies.
Medical students in Second Opinions, a student-run pro-bono consulting group, shared their experiences consulting for local healthcare nonprofits at a recent lecture.
Across the medical school, investigators are leading grants for community-engaged research projects that tackle a wide range of specific health challenges in Chicagoland and beyond.
A combination of three therapies was found to provide the greatest benefit to patients with metastatic breast cancer classified as HER2- and hormone receptor-positive, who aren’t candidates for chemotherapy, according to a Northwestern Medicine clinical trial.
An emergency department program focused on geriatric transitional care has reduced the risk of unnecessary admission of older patients at Northwestern Medicine by 33 percent.
Obese, middle-age men and women who had bariatric surgery have half the death rate of those who had traditional medical treatment over a 10-year period.
Long-term studies also haven’t proven how much routine screening can help reduce the number of adults with scoliosis who suffer from breathing problems, back pain, disability or reduced quality of life, the Task Force points out. Parents should still see a doctor if they’re concerned that their child might have scoliosis, said Dr. John Francis Sarwark, author of an accompanying editorial in JAMA and a researcher at the Northwestern University Feinberg School of Medicine and the Ann & Robert H. Lurie Children’s Hospital of Chicago.
No one knows precisely what purpose lp(a) serves in the body, though some scientists speculate that it may have a beneficial role such as helping to repair injured cells or preventing infections by binding to pathogens in the blood. But the downside of excessive lp(a) is clear: It accelerates the formation of plaque in the arteries, and it promotes blood clots. “It’s sort of a double whammy,” said Dr. Donald Lloyd-Jones, a cardiologist at the Northwestern University Feinberg School of Medicine who helped write the American Heart Association’s cholesterol guidelines. “Biologically, lp(a) both gets into the artery wall and causes damage there more easily.”
Medicare says it performs spot checks, but Dr. Karl Bilimoria, director of the Surgical Outcomes and Quality Improvement Center at the Northwestern University Feinberg School of Medicine, says more policing is needed for the rates to be credible. “In no other industry would this pass, where a program without an audit and [with] voluntary data reporting would be considered valid,” Bilimoria says. “We know guys are gaming.”
Over one in five Americans between the ages of 40 and 75 already take a statin to prevent an initial heart attack or stroke, the American study from 2017 estimated. Following either of the guidelines consistently would add millions to that list, and the ACC/AHA recommendation in particular would more than double it. Pencina said that much of the difference — 9.3 million people — includes those under 60 and those with diabetes. Some of these people may have a low 10-year risk, he said, but a relatively high 30-year risk.The guidelines “highlight many, many important similarities much more than it highlights some small differences,” said Dr. Don Lloyd-Jones, a spokesperson for the AHA and a professor of preventive medicine at Northwestern University Feinberg School of Medicine.