Tag: Pathology
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Oxidative Stress Drives Rare Disease Flare-ups, Study Finds
Northwestern Medicine scientists have uncovered a mechanism that may explain why people with Darier disease, a rare genetic skin disorder, often develop symptoms years after birth and experience painful flare-ups triggered by heat, sunlight and psychological stress.
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Gut Bacteria Leave Intestinal ‘Memory,’ Protecting Against Inflammation
New Northwestern Medicine research published in Nature Communications suggests that a metabolite produced by gut bacteria when they digest dietary fiber can leave a lasting molecular imprint on intestinal cells, promoting immune tolerance and protecting against inflammatory bowel disease-like conditions long after exposure ends.
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Blood Cell ‘Nurseries’ Upend Understanding of Human Physiology
Northwestern Medicine scientists have discovered that one of the body’s most fundamental biological processes — how red blood cells are made — works differently in humans than previously thought, according to a new study published in Nature Genetics.
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Identifying Immune Pathways Driving Aggressive Brain Cancers
A new study has uncovered a key mechanism that helps one of the deadliest brain cancers evade the immune system, according to the study published in The Journal of Clinical Investigation.
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Cells ‘Switch’ on Protein Factories After Injury, Study Finds
Scientists have uncovered a novel mechanism through which skin cells organize and control protein production during homeostasis and wound healing, according to a new study published in Developmental Cell.
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Transcription Factors Form Continuous ‘Circuit’ That Regulates T-cell Exhaustion
Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion and migration during viral infection, which may inform future therapeutic strategies for managing infections and cancer, according to a recent Northwestern Medicine study.
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Uncovering a Genetic Driver of Rare Early-Onset Dementia
A global team of scientists has uncovered a new genetic risk factor for a rare and aggressive form of early-onset dementia, according to a study published in Nature Genetics.
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Novel Biomarker May Predict Immunotherapy Resistance
Northwestern Medicine scientists have identified a novel biomarker for immune immunotherapy resistance in cancer that may also serve as a potential therapeutic target for patients who don’t respond well to immunotherapy, according to a recent study published in The Journal of Clinical Investigation.
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Molecular Mechanisms Support Long-term Immunity
Scientists in the laboratory of Weiguo Cui, PhD, have identified novel molecular mechanisms that help specialized T-cells maintain long-term immunity in response to chronic infection and cancer, according to recent findings published in Nature Immunology.
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How a ‘DNA Detangler’ Gene Protects Against Blood Cancer
A new Northwestern Medicine study has revealed how a common inherited mutation disrupts red blood cell development and sparks inflammation that may lead to leukemia, according to findings published in Nature Communications.
