Tag: Pathology
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Targeting T-cell Lipid Metabolism May Improve Cancer Immunotherapy
Investigators have discovered that targeting specific mechanisms linked to lipid metabolism in immune cells within tumors may improve response to current and future cancer immunotherapies, according to a recent study published in the journal Immunity.
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Molecular Profiling May Improve Meningioma Decisionmaking
Investigators have demonstrated how molecular profiling of tumors can be used to help predict treatment response and survival in patients with meningiomas, the most common type of primary brain tumor, according to a recent study published in Nature Medicine.
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Protein May Hold Key to Transplant Tolerance
Northwestern Medicine investigators have uncovered how a single protein contributes to heart transplant tolerance in mice, according to a study published in the Proceedings of the National Academy of Sciences.
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New Mechanisms Underlying Tumor Variety in Brain Cancers Discovered
Investigators have discovered new mechanisms underlying intratumor heterogeneity and treatment resistance in meningiomas, the most common type of primary central nervous system tumor, according to a recent study published in Nature Genetics.
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Novel Regulator of Immune Evasion in Cancer Identified
Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future anti-tumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.
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Combination Immunotherapy Shows No Additional Benefit for Most Advanced Cancers
A combination immunotherapy treatment of nivolumab plus ipilimumab was associated with no improvement in survival for advanced cancers other than melanoma, when compared to nivolumab alone, according to a recent Northwestern Medicine meta-analysis published in JAMA Oncology.
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Novel Intercellular Signaling Mechanisms Promote Melanoma Growth
Investigators have discovered novel intercellular “crosstalk” between epidermal keratinocytes and melanoma cells that promotes cancer growth and metastasis, which could also serve as biomarkers for early cancer detection, according to a recent Northwestern Medicine study.
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Uncovering the Molecular Underpinnings of Inflammation
Northwestern Medicine investigators have identified new molecular details regarding how white blood cells move across the walls of microvessels during inflammation, revealing new potential molecular targets for treating the condition, according to a new study published in the journal Immunity.
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Study Identifies Mechanisms Driving Immune Cell Recruitment During Inflammation
Northwestern Medicine investigators have discovered a novel mechanism that regulates neutrophil recruitment into tissue during inflammation, which could be targeted to treat different inflammatory diseases and conditions, according to a recent study published in the Journal of Clinical Investigation.
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Coaxing Hair Growth in Aging Hair Follicle Stem Cells
Northwestern scientists discovered how to soften hair follicle stem cells to enable them to grow hair again, according to a study published in Proceedings of the National Academy of Sciences.
