Tag: Microbiology-Immunology
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Delayed Antibody Treatment May Improve Efficacy of mRNA Vaccines
Investigators led by Pablo Penaloza-MacMaster, PhD, associate professor of Microbiology-Immunology, have discovered that administering an antibody treatment four days after mRNA vaccination significantly improved vaccine efficacy in mice, according to findings published in The Journal of Clinical Investigation.
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Targeting T-cell Lipid Metabolism May Improve Cancer Immunotherapy
Investigators have discovered that targeting specific mechanisms linked to lipid metabolism in immune cells within tumors may improve response to current and future cancer immunotherapies, according to a recent study published in the journal Immunity.
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Uncovering Regulatory Mechanisms of T-cells in Chronic Inflammation
Northwestern Medicine scientists have discovered a new underlying mechanism that controls a specialized group of T-cells, findings that may serve as potential targets for treating inflammatory diseases and cancer, according to a recent study.
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Spike Mutations Help SARS-CoV-2 Infect the Brain
Northwestern Medicine scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system, according to recent findings.
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Intracellular Mechanisms Promote Spread of Deadly Bacterial Infection
Northwestern Medicine investigators have discovered novel protein mechanisms that promote the rapid spread of Vibrio vulnificus, a rare but lethal bacteria that can cause vibriosis and sepsis, according to findings published in Proceedings of the National Academy of Sciences.
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Weakened Virus Helps Eliminate Cancer
Northwestern Medicine scientists have discovered that a weakened form of a virus can be used to help eliminate cancer in mice.
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How Herpes Hijacks a Ride into Cells
Northwestern Medicine scientists have discovered how herpes viruses hijack cellular transport processes to infiltrate the nervous system, according to a study published in the Proceedings of the National Academy of Sciences.
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Targeting Protein Interactions May Boost Antitumor Immunity in Breast Cancer
A multi-institutional team of investigators has discovered that targeting a specific protein interaction within immunosuppressive breast cancer cells may increase antitumor immune responses, according to findings published in the Journal of Clinical Investigation.
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Novel Mechanism Supports Antitumor Response and T-cell Survival
A recent Northwestern Medicine study has discovered a previously unknown molecular mechanism that supports antitumor responses and cell survival in cytotoxic immune cells, according to findings published in the Journal of Clinical Investigation.
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Release of Inhibitory Pathways May Promote Immune Response to HIV
Recent work from the laboratory of Elena Martinelli, PhD, MPH, has discovered how inhibiting an immune cell singling pathway in a model of HIV-1 infection may promote immune responses and decrease viral persistence in conjunction with antiretroviral therapy.
